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Antipressor and Depressor Effects of Oxidation Products of Pressor Amines

Abstract

PRESSOR amines comprise a great variety of Î-substituted primary and secondary alkylamines the cyclic portion of which may contain one or two phenol groups. The various functional groups determine the catabolic fate of these amines which, in turn, contribute to the nature, intensity and duration of their action. Because of the role attributed to pressor amines in essential1 and in experimental2 hypertension, the mechanism of their inactivation and destruction is of pathological and pharmacological interest.

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References

  1. Oster, K. A., and Sorkin, S. Z., "Effects of Intravenous Injections of 1-Dopa upon Blood Pressure" (in the press).

  2. Bing, R. J., Amer. J. Phys., 132, 497 (1941).

    Article  CAS  Google Scholar 

  3. Guggenheim, M., "Die biogenen Amine", 3rd edition (Basel, 1940).

    Google Scholar 

  4. Arnow, L. E., J. Biol. Chem., 120, 151 (1937).

    CAS  Google Scholar 

  5. Raper, H. S., Biochem. J., 21, 89 (1927).

    Article  CAS  Google Scholar 

  6. Schroeder, H. A., and Adams, M. K., J. Exp. Med., 73, 531 (1941).

    Article  CAS  Google Scholar 

  7. Soloway, S. O., and Oster, K. A., Proc. Soc. Exp. Biol. Med., 50, 108 (1942).

    Article  CAS  Google Scholar 

  8. Green, D. E., and Richter, D., Biochem. J., 31, 596 (1937).

    Article  CAS  Google Scholar 

  9. Oster, K. A., and Sobotka, H., "Effect of 5,6-Diketo-tetrahydrindole Derivatives on Blood Pressure" (in preparation).

  10. Kisch, B., and Oppenheimer, C., "Handb. d. Biochem.", Suppl., I, 563 (1933).

  11. Beyer, K. H., J. Pharm. Exp. Ther., 71, 394 (1941).

    CAS  Google Scholar 

  12. Hare, M. L. C., Biochem. J., 22, 965 (1928).

    Article  Google Scholar 

  13. Bernheim, M. L. C., J. Biol. Chem., 93, 299 (1931).

    CAS  Google Scholar 

  14. Robinson, R., J. Chem. Soc., 1079 (1936). Hahn, O., and Schales, K., Ber. Chem. Ges., 68, 24 (1935). Schopf, G., and Angew, Chem., 50, 779, 797 (1937).

    Article  Google Scholar 

  15. Holtz, P., Heise, C., and Luedtke, C., Arch. Exp. Path. u. Pharm., 191, 87 (1938).

    Article  CAS  Google Scholar 

  16. Goodman, L., and Gilman, A., "The Pharmacological Basis of Therapeutics", 403 (New York, 1941).

    Google Scholar 

  17. Feulgen, R., and Voit, K., Pfluegers Arch., 206, 389 (1924). Feulgen, R., and Bersin, Th., Z. physiol. Chem., 206, 217 (1939).

    Article  CAS  Google Scholar 

  18. Feulgen, R., Imhaeuser, K., and Behrens, M., Z. physiol. Chem., 180, 101 (1929).

    Article  Google Scholar 

  19. Oster, K. A., Schlossmann, N. C., and Sobotka, H., "Histochemical Demonstration of Amine Oxidase; Chemical Nature of the Higher Fatty Aldehydes in the Hog Kidney" (in preparation).

  20. Harrison, F. R., Grollman, A., and Willams, J. R., jr., Amer. J. Phys., 128, 116 (1940). Page, I. H., Helmer, O. M., Kohlstaedt, K. G., Fonts, P. J., Kempf, G. F., and Corcoran, A. C., Proc. Soc. Exp. Biol. and Med., 43, 722 (1940).

    Google Scholar 

  21. Goldblatt, H., Lynch, J., Hanzal, R. F., Summerville, W. W., J. Exp. Med., 59, 547 (1934).

    Article  Google Scholar 

  22. Philpot, F. J., Biochem. J., 31, 856 (1937). Oster, K. A., Solway, S. J., J. Mount Sinai Hosp. (in the press).

    Article  CAS  Google Scholar 

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OSTER, K. Antipressor and Depressor Effects of Oxidation Products of Pressor Amines. Nature 150, 289–290 (1942). https://doi.org/10.1038/150289a0

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