Abstract
Robson and Schönberg1 have shown that triphenylethylene, a synthetic substance which is easily prepared and now commercially obtainable, will induce œstrous changes in the genital organs and mating in ovariectomized mice and hypophysectomized rabbits. The effect in mice may last for several months. Robson2 has reported on the induction of œstrous changes in the monkey and bitch by triphenylethylene. He stated also that no toxic changes were observed in these animals or in mice injected with large doses of triphenylethylene3.
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References
Robson and Schönberg, NATURE, 140, 196 (1937).
Robson, Proc. Soc. Exp. Biol., 38, 153 (1938).
Lately more powerful derivatives of triphenylethylene have been discovered. Compare Schönberg, Robson, Tadros and Fahim, J. Chem. Soc., 1327 (1940); and Robson, Schönberg and Fahim, NATURE, 142, 292 (1938).
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SCHÖNBERG, A., GHONEIM, A. Influence of the Synthetic œstrogen Triphenylethylene on the Growth and Egg–laying Capacity of Poultry. Nature 148, 468–469 (1941). https://doi.org/10.1038/148468b0
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DOI: https://doi.org/10.1038/148468b0
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