Abstract
DURING investigations of the Prague sero reactions for cancer we have tried to identify the substances in the serum, which give the typical polarographic curve when using the technique of Brdička described in our previous letter as preparation (b)1. According to Brdi&cbreve;ka2, this curve form is characteristic for compounds of cystine; the concentration of cystine must, however, be 100–1,000 times greater than that generally found in serum (1 mgm. per cent3), if it is to be responsible for the heights of the curve, found by Brdicka and ourselves in serum. Furthermore, we have found similar curves by submitting urine to the polarograph instead of serum, and we find that the concentration of cystine in normal urine is exceedingly small.
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References
Bergh, Henriques, Schousboe, [NATURE, 141, 751 (1938).
Brdi&cbreve;ka, Acta internat. Verein. Krebsbekämpfung, 3, 13 (1938).
Brown, Lewis, Proc. Soc. Exp. Biol., Med., 36, 487 (1937).
Waldschmidt-Leitz, Angewandte Chem., 51, 324 (1938).
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BERGH, F., HENRIQUES, O. & WOLFFBRANDT, C. Prague Sero Reactions for Cancer. Nature 142, 212–213 (1938). https://doi.org/10.1038/142212a0
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DOI: https://doi.org/10.1038/142212a0
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