Abstract
IN the course of experiments designed for the practical purpose of finding the most suitable conditions for the assay of hæmostatic surgical dressings containing thrombin, we have encountered a bloodclotting phenomenon which is apparently new. Not all the thrombin present can readily be extracted from these dressings, so that a new method has to be used for the estimation, depending on the measurement of the amount of clot produced on the fabric by soaking in an excess of citrated blood under specified conditions, the whole specimen being subjected to micro-Kjeldahl nitrogen estimation after removing the unclotted blood by washing. The quantity of clot is measured in milligrams of nitrogen per sq. cm. of fabric.
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References
Landsberg, W., Biochem. Z., 50, 245 (1913).
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SAVAGE, R., CHAMBERS, W. Optimum Temperature of Formation of a Blood Clot. Nature 141, 287–288 (1938). https://doi.org/10.1038/141287a0
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DOI: https://doi.org/10.1038/141287a0
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