Abstract
FLÜRSCHEIM1 made the classical observation that substituent atoms or groups influence the dissociation of carboxylic acids and amines in a manner related to their effect on further substitution in benzene derivatives containing them. This has led, directly or indirectly, to much further work which has established that this type of qualitative relationship applies to the velocities of a wide variety of reactions and to a number of dissociations. The results have been extensively discussed either in terms of Flürscheim's Theory of Valency or in terms of the electronic theory which has incorporated the essential elements of the earlier conception. But these discussions have been concerned with sequences of groups or other qualitative considerations.
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BURKHARDT, G. Influence of Substituents on Organic Reactions: a Quantitative Relationship. Nature 136, 684 (1935). https://doi.org/10.1038/136684a0
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DOI: https://doi.org/10.1038/136684a0
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