Abstract
BROUHA and Simonnet1 have already given evidence that testicular extracts produce æstrus in castrated rats, as shown by the cornification test, causing also the proliferation of the uterine mucous membrane in immature female rats. A similar reaction has been observed after injections of the male hormone extracted from the urine (hombreol)2. The horns of the uterus increase, their lumens fill up with the excreted fluid, the glands and muscular layers are better developed and the epithelial cells become elongated. These changes are comparable to those caused by the female sex hormone. The fact that both the female and the male hormones affect the genital tract of the female similarly is, I think, in accord with the results of recent biochemical work3,4. It is interesting to note that the proliferational changes are most striking in animals treated simultaneously with the male and female hormones.
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C. R. Soc. Biol., 99; 1928.
St. Skowron and E. Turyna, Pol. Gaz. Lek., Nr. 18; 1934.
W. Schoeller, E. Schwenk and F. Hildebrandt, Naturwiss., Jahrg. 21, 1933.
W. Dirscherl and H. E. Voss, Naturwiss., Jahrg. 22, 1934.
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SKOWRON Effect of the Male Sex Hormone on the Genital Tract of the Female. Nature 134, 627 (1934). https://doi.org/10.1038/134627c0
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DOI: https://doi.org/10.1038/134627c0
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