Abstract
THE conclusion having been reached that vitamin C is identical with hexuronic acid, it becomes of obvious importance in the first place to see how this can be reconciled with Zilva's contention1 that there is a lack of parallelism between antiscorbutic activity and reducing capacity—one of the most characteristic properties of hexuronic acid. Fig. 1 summarises all the data given by Zilva, mean values for antiscorbutic potencies being plotted at each level of reducing capacity. Bearing in mind the unavoidable variation in biological response between individual experimental animals, it becomes evident that Zilva's data, once they are analysed in this way, appear in fact to afford good evidence of a close quantitative relation between reducing capacity and antiscorbutic activity in lemon juice fractions, and therefore are not at variance with the hypothesis that hexuronic acid and vitamin C are identical.
Similar content being viewed by others
Article PDF
References
Zilva, Biochem. J., 26, 1624; 1932.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DANN, W. Hexuronic (Ascorbic) Acid as the Antiscorbutic Factor, and its Chemical Determination. Nature 131, 274 (1933). https://doi.org/10.1038/131274a0
Issue Date:
DOI: https://doi.org/10.1038/131274a0
This article is cited by
-
Enthalten die Gebräuchlichen Leberpräparate Vitamin C
Klinische Wochenschrift (1935)
-
Die Ausscheidung der Ascorbinsäure im Gesunden und Kranken Organismus
Klinische Wochenschrift (1935)
-
Constitution of Vitamin C
Nature (1933)
-
Constitution of Ascorbic Acid
Nature (1933)
-
Indophenol Reducing Capacity of Lemon Juice and its Fractions in Relation to Vitamin C Activity
Nature (1933)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.