Abstract
DUDLEY1 has shown that the action of tissue extracts in converting methyl glyoxal to lactic acid, or phenyl glyoxal to mandelic acid, is inhibited by iodoacetic acid. Lohmann2 considers, however, that this is probably not the cause of the poisoning action of iodoacetate on animal tissues, since, in the case of the crude extracts used, a much higher concentration of iodoacetate was needed than that required to stop glycolysis.
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References
Biochem. J., 25, 439; 1931.
Biochem. Z., 236, 444; 1931.
Biochem. Z., 254, 332; 1932.
Naturwiss., 20, 122; 1932.
Biochem. Z., 248, 3; 1932.
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DICKENS, F. Iodoacetic Acid, Glutathione and Tissue Glyoxalase. Nature 131, 130–131 (1933). https://doi.org/10.1038/131130c0
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DOI: https://doi.org/10.1038/131130c0
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