Abstract
SINCE Loeffler and Frosch in 1897 reported the striking fact that the fluid from the vesicles which form the main outward lesion of foot-and-mouth disease in bovines, could, after dilution with water, be passed through kieselguhr filters without suffering loss of potency, it has been customary to regard the virus of this, perhaps the most contagious of all animal diseases, as belonging to the group of ultra-visible or filter-passing viruses. This demonstration by Loeffler and Frosch was, indeed, the first indication that an animal disease might be associated with a virus the minute size of which permitted it to pass with ease through filters which retained the ordinary microscopic bacterial forms.
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Research on Foot-and-Mouth Disease. Nature 116, 489–490 (1925). https://doi.org/10.1038/116489a0
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DOI: https://doi.org/10.1038/116489a0