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Blood pressure and its reactivity in the offspring of first cousin hypertensive and first cousin normotensive parents: a preliminary report

Journal of Human Hypertension volume 15, pages 869–872 (2001)Cite this article

Abstract

The aim of this preliminary study was to determine whether young offspring of first cousin hypertensive parent(s), have higher blood pressure (BP) reactivity in response to their first BP measurement, as compared to the offspring of first cousin normotensive parents. The BP of 135 boys aged 9–10 years was measured, for the first time ever, after a 10-min supine rest, and subsequently, twice at 10-min intervals. The offspring of first cousin hypertensive parent(s) reacted with significantly higher systolic and diastolic BP than the offspring of normotensive first cousin parents in all three measurements. This study indicates that at an early age, the offspring of first cousin hypertensive parents, react with exaggerated BP response at their first casual BP measurement. We hypothesise that familial aggregation of BP may show more expression amongst the offspring of consanguineous marriage of hypertensive parent(s).

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References

  1. Stamler R et alFamilial (parental) History and prevalence of hypertension JAMA 1979 241 43–46

    Article  CAS  PubMed  Google Scholar 

  2. Havlik RJ et alBlood pressure aggregation in families Am J Epidemiol 1979 110 304–312

    Article  CAS  PubMed  Google Scholar 

  3. Hunt SC et alGenetic heritability and common environmental components of resting and stressed blood pressure, lipids, and body mass index in Utah pedigrees and twins Am J Epidemiol 1989 129 625–638

    Article  CAS  PubMed  Google Scholar 

  4. Watt G Design and interpretation of studies comparing individuals with and without a family history of high blood pressure J Hypertens 1986 4 1–7

    Article  CAS  PubMed  Google Scholar 

  5. Muldoon MF, Terrell DF, Bunker CH, Manuck SB Family history studies in hypertension research: review of the literature Am J Hypertens 1993 6 76–68

    Article  CAS  PubMed  Google Scholar 

  6. Bouchard TJ et alSources of human physiological difference: The Minnesota Study of Twins Reared Apart Science 1990 250 223–228

    Article  PubMed  Google Scholar 

  7. Hong Y et alGenetic and environmental influences on blood pressure in elderly twins Hypertension 1994 24 663–670

    Article  CAS  PubMed  Google Scholar 

  8. Mo R, Omvik P, Lund-Johansen P The Bergen blood pressure study: offspring of two hypertensive parents have significantly higher blood pressures thanoffspring of one hypertensive and one normotensiveparent J Hypertens 1995 13 1614–1617

    CAS  PubMed  Google Scholar 

  9. Zinner SH, Levy PS, Kass EH Familial aggregation of blood pressure in childhood N Engl J Med 1971 284 401–404

    Article  CAS  PubMed  Google Scholar 

  10. Carmelli D et alGenetic effects on cardiovascular responses to cold and mental activity in late adulthood Am J Hypertens 1991 4 239–244

    Article  CAS  PubMed  Google Scholar 

  11. Bielen FC, Fagard RH, Amery AK Inheritance of blood pressure and hemodynamic phenotypes measures at rest and during supine dynamic exercise J Hypertens 1991 9 655–663

    Article  CAS  PubMed  Google Scholar 

  12. Lemne CE Increased blood pressure reactivity in children of borderline hypertensive fathers J Hypertens 1998 16 1243–1248

    Article  CAS  PubMed  Google Scholar 

  13. Hamet P et alHypertension: genes and environment J Hypertens 1998 16 397–418

    Article  CAS  PubMed  Google Scholar 

  14. Verdecchia P White-coat hypertension in adults and children Blood Press Monit 1999 4 175–179

    CAS  PubMed  Google Scholar 

  15. Kario K, Pickering TG Survey of white coat hypertension BMJ 1999 318 535

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. De Faire U, Lindvall K, Nilsson B Noninvasive ambulatory 24 h blood pressure and basal pressures predict development of sustained hypertension from a borderline state Am J Hypertens 1993 6 149–155

    Article  CAS  PubMed  Google Scholar 

  17. Georgiades A, Lemne C, de Faire U, Fredricksson M Stressıinduced blood pressure in relation to ambulatory pressure and left ventricular mass among borderline hypertensives and normotensives Hypertension 1996 28 641–646

    Article  CAS  PubMed  Google Scholar 

  18. Sulaiman AJ, Al Riyami A, Farid S Oman Family Health Survey Ministry of Health: Muscat 1995 pp 45–46

    Google Scholar 

  19. El Mugamer IT, Ali Zayat AS, Hossain MM, Pugh RN Diabetes, obesity and hypertension in urban and rural people of bedouin origin in the United Arab Emirates J Trop Med Hyg 1995 98 407–415

    CAS  PubMed  Google Scholar 

  20. Ibrahim MM The Egyptian national Hypertension Project (NHP); Preliminary results J Hum Hypertens 1996 10 (Suppl 1) S39–S41

    Google Scholar 

  21. Berg K Gene-environment interaction; variability gene concept. In: Goldbourt U, de Faire U, Berg K (eds) Genetic Factors in Coronary Heart Disease Dortrecht Kluwer Academic Publishers 1994 pp 153–177

    Google Scholar 

  22. Grim CE On Slavery, salt and the greater prevalence of hypertension in black Americans Clin Res 1988 36 340–347

    Google Scholar 

  23. Wilson TW, Grim CE Biohistory of slavery and blood pressure differences in blacks today: a hypothesis Hypertension 1991 17 (Suppl 1) 1122–1128

    Google Scholar 

  24. Tiret L et alGene polymorphisms of the renin-angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke: the PEGASE study J Hypertens 1998 16 37–44

    Article  CAS  PubMed  Google Scholar 

  25. Caulfield M et alLinkage of the angiotensinogen gene to essential hypertension N Engl J Med 1994 330 1629–1633

    Article  CAS  PubMed  Google Scholar 

  26. Frossard PM, Obineche EN, Elshahat YL, Lesteringant GG Deletion polymorphism in the angiotensin-converting converting enzyme gene is not associated with hypertension in a Gulf Arab population Clin Genet 1997 51 211–213

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This project is funded by Sultan Qaboos University internal grant system, number IG/MED/PHYS/ 00/01.

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  1. Department of Physiology, College of Medicine, Sultan Qaboos University and Khoula Hospital, Ministry of Health, Muscat, Sultanate of Oman

    MO Hassan, W Al Kharusi & A Ziada

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  1. MO Hassan
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  2. W Al Kharusi
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  3. A Ziada
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Correspondence to MO Hassan.

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Hassan, M., Al Kharusi, W. & Ziada, A. Blood pressure and its reactivity in the offspring of first cousin hypertensive and first cousin normotensive parents: a preliminary report. J Hum Hypertens 15, 869–872 (2001). https://doi.org/10.1038/sj.jhh.1001284

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