Abstract
The objective of this study was to compare the quality of life and incidence of dry cough with the angiotensin II antagonist eprosartan, the ACE-inhibitor enalapril, and placebo, in hypertensive patients with a history of ACE-inhibitor cough. The study was a multicentre, randomised, double-blind, parallel group controlled trial. A total of 136 patients judged to have ACE-inhibitor cough during single-blind enalapril treatment which was lost during a subsequent placebo washout phase, were randomised to receive either eprosartan 300 mg twice daily, or enalapril 20 mg once daily, or placebo for 6 weeks. Self-completion questionnaires assessing quality of life and cough were examined at baseline and end of study. At study end point 23% of patients in the enalapril group and 5% in the eprosartan and placebo groups reported cough (which included definite, probable and possible coughs) (P = 0.02). After adjusting for multiple comparisons, the eprosartan group was not significantly different from either placebo or enalapril. There were no significant differences in the Psychological General Wellbeing Index (PGWB). In conclusion the incidence of self-reported cough on eprosartan was similar to that on placebo, and lower than on enalapril but this difference was not significant when adjustments were made for multiple comparisons. There were no differences in quality of life.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fletcher AE, Palmer AJ, Bulpitt CJ Cough with angiotensin converting enzyme inhibitors: how much of a problem? J Hypertens 1994 12 (Suppl 2) S43–S47
Yeo WW, Ramsay LE Persistent dry cough with enalapril: incidence depends on method used J Hum Hypertens 1990 4 517–520
Lacourcière Yet al,and the Losartan Cough Study GroupEffects of modulators of the renin-angiotensin-aldosterone system on cough J Hypertens 1994 12 1387–1393
Ramsay LE, Yeo WW, on behalf of the Losartan Cough Study Group ACE inhibitors, angiotensin II antagonists and cough J Hum Hypertens 1995 9 (Suppl 5) S51–S54
Ramsay LE, Yeo WW, on behalf of the Losartan Cough Study Group Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensivepatients with a previous angiotensin converting enzyme inhibitor-associated cough J Hypertens 1995 13 (Suppl 1) S73–S76
Chan P et alDouble-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensivepatients with previous angiotensin-converting enzyme inhibitor-induced cough J Clin Pharmacol 1997 37 253–257
Dupuy HJ The Psychological General Wellbeing Index. In: Wenger NK, Mattson ME, Furberg CD,Eliason J (eds) Assessment of Quality of Life in Clinical Trials of Cardiovascular Therapies Le Jacq: New York 1984 pp 170–183
Wiklund I, Halling K, Lngström G The Psychological General Wellbeing Index (PGWB), a reliable tool for use in cross-cultural multicentre clinical trials (abstract) Qual Life Res 1995 4 503
Badia X, Gutiérrez F, Wiklund I, Alonso J Validity and reliability of the Spanish version of the Psychological General Wellbeing Index Qual Life Res 1996 5 101–108.
Bulpitt CJ, Fletcher AE Measurements of quality of life in hypertension: a practical approach Br J Clin Pharmacol 1990 30 353–364
Crown S, Crisp AH A short diagnostic self-rating scale for psychoneuroticpatients Br J Psychiatr 1966 112 917–923
Developed in the Rand Corporation, Santa Monica, California
Kazis LE, Anderson JJ, Meenan RS Effect sizes for interpreting changes in health statistics Med Care 1989 27 178–189
Hochberg Y A sharper Bonferroni procedure for multiple tests Biometrika 1988 75 800–802
Paster RZ et alUse of Iosartan in the treatment of hypertensivepatients with a history of cough induced by antiotensin-converting enzyme inhibitors Clin Ther 1998 20 978–989
Reisin L, Schneeweiss A Complete spontaneous remission of cough induced by ACE-inhibitors during chronic therapy in hypertensivepatients J Hum Hypertens 1992 6 333–335
Reisin L, Schneeweiss A Spontaneous disappearance of cough induced by angiotensin-converting enzyme inhibitors (captopril or enalapril) Am J Cardiol 1992 70 398–399
Israili ZH, Hall WD Cough and angioneurotic oedema associated with angiotensin converting enzyme inhibitor therapy Ann Intern Med 1992 117 234–242
Yeo WW, Foster G, Ramsay L Prevalence of persistent cough during long term enalapril treatment: controlled study versus nifedipine Q J Med 1991 293 763–770
Os I et alFemale sex as an important determination of lisinopril-induced cough (letter) Lancet 1992 339 372
Acknowledgements
The project was funded by Smithkline Beecham Pharmaceutical Inc (since merged into GlaxoSmithkline).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rake, E., Breeze, E. & Fletcher, A. Quality of life and cough on antihypertensive treatment: a randomised trial of eprosartan, enalapril and placebo. J Hum Hypertens 15, 863–867 (2001). https://doi.org/10.1038/sj.jhh.1001283
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.jhh.1001283
Keywords
This article is cited by
-
Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital
Clinical Hypertension (2019)
-
Tolerability of Angiotensin-Receptor Blockers in Patients with Intolerance to Angiotensin-Converting Enzyme Inhibitors
American Journal of Cardiovascular Drugs (2012)
-
Antihypertensive effects and safety of eprosartan: a meta-analysis of randomized controlled trials
European Journal of Clinical Pharmacology (2012)
-
Diabetes, hypertension, and cardiovascular derangements: Pathophysiology and management
Current Hypertension Reports (2004)