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Antiphospholipid syndrome

Can transcriptomics guide the management of SLE-associated APS?

Nature Reviews Rheumatology (2024)Cite this article

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The management of antiphospholipid syndrome is hindered by heterogeneous clinical presentations. Whole-blood transcriptomics have the potential to identify previously unknown disease endotypes, which could inform new treatment strategies. However, such hypothesis-generating data must still account for the results of randomized clinical trials, such as those focused on direct oral anticoagulants in APS.

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Acknowledgements

We thank M. Crowther, P. Meroni and V. Pengo for helpful conversations on this subject.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    Jason S. Knight

  2. Rheumatology Unit, First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece

    Maria G. Tektonidou

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  1. Jason S. Knight
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Correspondence to Maria G. Tektonidou.

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Knight, J.S., Tektonidou, M.G. Can transcriptomics guide the management of SLE-associated APS?. Nat Rev Rheumatol (2024). https://doi.org/10.1038/s41584-024-01123-7

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