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Immune cells coordinate β-cell insulin secretion to regulate glucose levels and promote type I interferon production to control systemic viral infection.
IDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Sepsis is a global challenge and a significant burden in Sub-Saharan Africa. Here, Chenoweth et al profile host gene expression signatures from a cohort in Ghana to define molecular phenotypes and identify potential targets to improve patient outcomes.
Sestan et al. find a conserved mechanism during systemic viral infection in which γδ T cells produce IFNγ to increase pancreatic insulin secretion, lowering blood glucose and then enhancing type I interferon-mediated protection against viral infection.
Immune cells coordinate β-cell insulin secretion to regulate glucose levels and promote type I interferon production to control systemic viral infection.
A modeling study marking 50 years of vaccination through the Expanded Programme on Immunization of the World Health Organization highlights its lifesaving impact on infant and child health.
Millions of people died of COVID-19 because the fundamental principle of equity between nations was ignored during the outbreak. That must not be allowed to happen again.
In this Journal Club, Yi Shi discusses a paper reporting that influenza virus infection in humans induces broadly cross-reactive and protective antibodies against the viral neuraminidase.