Featured
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Technology Feature |
Powerful ‘nanopore’ DNA sequencing method tackles proteins too
Latest methods bring the speed, portability, and long read lengths of nanopore sequencing to proteomics.
- Caroline Seydel
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Research Briefing |
Quantum tunnelling of electrons brings ultrafast optical microscopy to the atomic scale
The oscillating electromagnetic fields that carry light can cause electrons to tunnel back and forth through a potential energy barrier. Remarkably, this alternating current can coherently emit measurable light waves — an unexpected process that can be exploited to build an optical microscope that undercuts existing spatial and temporal limitations.
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Article
| Open AccessThe intrinsic substrate specificity of the human tyrosine kinome
An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase regulation in phosphoproteomics experiments.
- Tomer M. Yaron-Barir
- , Brian A. Joughin
- & Jared L. Johnson
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Article |
Label-free detection and profiling of individual solution-phase molecules
Enhanced light–molecule interactions in high-finesse fibre-based Fabry–Pérot microcavities are used to detect and profile individual unlabelled solution-phase biomolecules, leading to potential applications in the life and chemical sciences.
- Lisa-Maria Needham
- , Carlos Saavedra
- & Randall H. Goldsmith
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News & Views |
Microbubble ultrasound maps hidden signs of heart disease
Cardiovascular disease claims more lives each year than do the two next-deadliest diseases combined. An ultrasound technique that tracks tiny gas-filled bubbles could pave the way towards improved early detection.
- Elisa E. Konofagou
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Spotlight |
How I’m supporting other researchers who have moved to Lithuania
Biochemist Stephen Knox Jones chose a role in the Baltic country over other faculty positions in Denmark and the United States. He explains why.
- Jacqui Thornton
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Spotlight |
I fell out of love with the lab, and in love with business
The COVID-19 pandemic changed Karolina Makovskytė’s career ambitions, propelling her to a business development role in her home nation of Lithuania.
- Jacqui Thornton
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Spotlight |
How bioinformatics led one scientist home to Lithuania
Juozas Gordevičius founded a data-science company in the United States before returning to Vilnius.
- Jacqui Thornton
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Obituary |
Allen J. Bard obituary: electrochemist whose techniques underpin clinical diagnostics, materials discovery and more
Innovator who pioneered scanning electrochemical microscopy, bioassays and solar fuels.
- Michael Rose
- & Henry S. White
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Spotlight |
A snapshot of Lithuania’s life-sciences landscape
Nature examines the Baltic country’s research ambitions as it marks 20 years of European Union membership.
- Jacqui Thornton
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News |
‘ChatGPT for CRISPR’ creates new gene-editing tools
Some of the AI-designed gene editors could be more versatile than those found in nature.
- Ewen Callaway
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Article
| Open AccessWhole-cortex in situ sequencing reveals input-dependent area identity
BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development.
- Xiaoyin Chen
- , Stephan Fischer
- & Anthony M. Zador
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Article
| Open AccessSpatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo
Topobiologically complex mini-colons—which enable the faithful in vitro recapitulation of colorectal cancer tumorigenesis and its environmental determinants—offer the possibility to reduce animal use in a wide range of experimental applications.
- L. Francisco Lorenzo-Martín
- , Tania Hübscher
- & Matthias P. Lutolf
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Career Feature |
Breaking ice, and helicopter drops: winning photos of working scientists
Nature’s annual photography competition attracted stunning images from around the world, including two very different shots featuring the Polarstern research vessel.
- Jack Leeming
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Outlook |
AI’s keen diagnostic eye
Powered by deep-learning algorithms, artificial intelligence systems could replace agents such as chemicals currently used to augment medical scans.
- Neil Savage
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Technology Feature |
A milestone map of mouse-brain connectivity reveals challenging new terrain for scientists
A pioneering ‘connectomics’ collaboration has successfully reconstructed one cubic millimetre of brain tissue, but researchers are still just scratching the surface of the complexity it contains.
- Michael Eisenstein
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News |
This fMRI technique promised to transform brain research — why can no one replicate it?
The DIANA technique sparked excitement from neuroscientists. But two new papers have cast doubt over the results.
- McKenzie Prillaman
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News & Views |
A bitter taste receptor activated in a surprising way
The sensing of bitter taste results from the complex interplay of many chemical cues and a range of receptors. It emerges that this complexity might be built-in even at the level of individual receptors.
- Antonella Di Pizio
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Article
| Open AccessSingle-cell multiplex chromatin and RNA interactions in ageing human brain
We introduce multinucleic acid interaction mapping in single cells (MUSIC), for concurrent profiling of multiplex chromatin interactions, gene expression and RNA–chromatin associations within individual nuclei, as a tool for exploring chromatin architecture and transcription.
- Xingzhao Wen
- , Zhifei Luo
- & Sheng Zhong
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Technology Feature |
One year, three researchers, millions of cells: how a small team created the largest mouse-embryo atlas so far
A map of mouse development from conception to birth tracks 12.4 million cells at single-cell resolution as they mature into organs and other tissues.
- Sara Reardon
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News & Views |
Powerful microscopy reveals blood-cell production in bone marrow
A method for imaging the production of blood cells in the bones of mice has revealed the organization of cell lineages, both in a steady state and in response to stressors, such as bleeding and infection.
- M. Carolina Florian
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Nature Video |
Building a heart atlas: researchers map organ in stunning detail
Cutting edge imaging techniques reveal how cells organise as the heart develops.
- Dan Fox
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Nature Index |
Four change-makers seek impact in medical research
Bringing fresh perspectives to long-standing health challenges, these scientists are using techniques such as big-data analytics and AI to push the field.
- Amy Coombs
- & Sandy Ong
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Article |
Universal recording of immune cell interactions in vivo
A paper reports the development of a universal tool for studying cellular interactions in biological systems, and demonstrates its coupling with single-cell transcriptomics methods to provide insights into the biology of the interactions.
- Sandra Nakandakari-Higa
- , Sarah Walker
- & Gabriel D. Victora
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Technology Feature |
How phase separation is revolutionizing biology
Imaging and molecular manipulation reveal how biomolecular condensates form and offer clues to the role of phase separation in health and disease.
- Elie Dolgin
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News |
MEGA-CRISPR tool gives a power boost to cancer-fighting cells
A system that edits RNA rather than DNA can give new life to exhausted CAR T cells.
- Sara Reardon
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Technology Feature |
Super-speedy sequencing puts genomic diagnosis in the fast lane
Streamlined workflows for DNA and RNA sequencing are helping clinicians to deliver prompt, targeted care to people in days — or even hours.
- Michael Eisenstein
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News |
Move over, CRISPR: RNA-editing therapies pick up steam
Two RNA-editing therapies for genetic diseases have in the past few months gained approval for clinical trials, raising hopes for safer treatments.
- Mariana Lenharo
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Article
| Open AccessGenetic determinants of micronucleus formation in vivo
Genetic screening identifies a rich catalogue of regulators of micronucleus formation.
- D. J. Adams
- , B. Barlas
- & G. Balmus
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News |
Turbocharged CAR-T cells melt tumours in mice — using a trick from cancer cells
Immune cells armed with a mutation first identified in cancer cells gain potency but don’t turn cancerous themselves.
- Asher Mullard
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Article
| Open AccessSingle-neuronal elements of speech production in humans
Neuropixels recordings from the language-dominant prefrontal cortex reveal a structured organization of planned words, an encoding cascade of phonetic representations by prefrontal neurons in humans and a cellular process that could support the production of speech.
- Arjun R. Khanna
- , William Muñoz
- & Ziv M. Williams
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News |
‘Wildly weird’ RNA bits discovered infesting the microbes in our guts
Rod-shaped structures named ‘obelisks’ are even smaller than viruses but can still transmit instructions to cells.
- Saima Sidik
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Outlook |
Tracking down tuberculosis
Improvements in screening and diagnosis could help to eradicate this curable disease.
- Neil Savage
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News |
CRISPR-edited crops break new ground in Africa
Scientists in the global south use the popular technique to protect local crops against local threats.
- Heidi Ledford
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Technology Feature |
Seven technologies to watch in 2024
Advances in artificial intelligence are at the heart of many of this year’s most exciting areas of technological innovation
- Michael Eisenstein
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Article
| Open AccessDeciphering cell states and genealogies of human haematopoiesis
An improved, single-cell lineage-tracing system, based on deep detection of naturally occurring mitochondrial DNA mutations with simultaneous readout of transcriptional states and chromatin accessibility, is used to define the clonal architecture of haematopoietic stem cells.
- Chen Weng
- , Fulong Yu
- & Vijay G. Sankaran
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Article
| Open AccessAffinity-optimizing enhancer variants disrupt development
Low-affinity transcription factor binding sites are prevalent across the genome, and single nucleotide changes that increase binding affinity even slightly can cause gain-of-function gene expression and phenotypes (such as polydactyly).
- Fabian Lim
- , Joe J. Solvason
- & Emma K. Farley
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Article
| Open AccessDe novo design of high-affinity binders of bioactive helical peptides
A study describes a direct computational approach without experimental optimization to design high-affinity proteins that bind small helical peptides.
- Susana Vázquez Torres
- , Philip J. Y. Leung
- & David Baker
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News & Views |
Gene expression of single cells mapped in tissue sections
A tool that tags individual cells in a tissue with a unique barcode means that the gene-expression profile of each cell can be plotted in its original location. This allows spatial information to be captured at single-cell resolution.
- Patrik L. Ståhl
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News |
Australian Indigenous genomes are highly diverse and unlike those anywhere else
In collecting genomic data for Indigenous Australians, scientists hope to expand knowledge of human genetic diversity and improve health for this group.
- Bianca Nogrady
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Article
| Open AccessSlide-tags enables single-nucleus barcoding for multimodal spatial genomics
Slide-tags enables multiomic sequencing of single cells and their localization within tissues.
- Andrew J. C. Russell
- , Jackson A. Weir
- & Fei Chen
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News |
How CRISPR gene editing could help treat Alzheimer’s
Some researchers hoping that gene-editing technology can conquer forms of Alzheimer’s caused by genetic mutations.
- Tosin Thompson
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News |
CRISPR 2.0: a new wave of gene editors heads for clinical trials
Landmark approval of the first CRISPR therapy paves the way for treatments based on more efficient and more precise genome editors.
- Heidi Ledford
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Research Briefing |
Atomic-level structures show how accuracy is maintained in protein synthesis
A series of structures of the eukaryotic protein-synthesis machinery are imaged at high resolution in defined states of the elongation phase of protein synthesis. Analysis suggests that there are underlying molecular mechanisms that increase the accuracy of translation of genetic information in eukaryotes.
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Technology Feature |
AI under the microscope: the algorithms powering the search for cells
Deep learning is driving the rapid evolution of algorithms that can automatically find and trace cells in a wide range of microscopy experiments.
- Michael Eisenstein
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Nature Video |
The 3D printer that crafts complex robotic organs in a single run
Combining machine vision with contactless error correction allows for even more advanced multi-material printing.
- Dan Fox
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Article
| Open AccessThe social and structural architecture of the yeast protein interactome
A protein interaction network constructed with data from high-throughput affinity enrichment coupled to mass spectrometry provides a highly saturated yeast interactome with 31,004 interactions, including low-abundance complexes, membrane protein complexes and non-taggable protein complexes.
- André C. Michaelis
- , Andreas-David Brunner
- & Matthias Mann
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Article
| Open AccessEmbryo-scale reverse genetics at single-cell resolution
We present the ‘zebrafish single-cell atlas of perturbed embryos’, single-cell trancriptomic data of developing zebrafish embryos across various timepoints and with genetic perturbations.
- Lauren M. Saunders
- , Sanjay R. Srivatsan
- & Cole Trapnell
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News & Views |
The deep route to low-field MRI with high potential
A type of magnetic resonance imaging, known as low-field MRI, could make the technique more widely accessible, but only if the image quality can be improved. A deep-learning protocol might hold the key.
- Patricia M. Johnson
- & Yvonne W. Lui
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