Featured
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Editorial |
AlphaFold3 — why did Nature publish it without its code?
Criticism of our decision to publish AlphaFold3 raises important questions. We welcome readers’ views.
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Article |
Legionella effector LnaB is a phosphoryl-AMPylase that impairs phosphosignalling
- Ting Wang
- , Xiaonan Song
- & Yongqun Zhu
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News & Views |
Cells cope with altered chromosome numbers by enhancing protein breakdown
When chromosomes are lost or gained, massive changes in gene expression disrupt the delicate balance of proteins in a cell. Yeasts with incorrect chromosome numbers counteract this by degrading excess proteins.
- Zuzana Storchová
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News |
Bizarre bacteria defy textbooks by writing new genes
Bacterial defensive systems scramble the standard workflow of life.
- Ewen Callaway
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News & Views |
AI networks reveal how flies find a mate
Artificial neural networks that model the visual system of a male fruit fly can accurately predict the insect’s behaviour in response to seeing a potential mate — paving the way for the building of more complex models of brain circuits.
- Pavan Ramdya
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Article
| Open AccessOsmosensor-mediated control of Ca2+ spiking in pollen germination
Screening in Escherichia coli and biochemical experiments show that in Arabidopsis thaliana, OSCA2.1 and OSCA2.2 function as plant sensors of hypo-osmolarity, utilize Ca2+ oscillations as second messengers and have crucial roles in pollen germination.
- Songyu Pei
- , Qi Tao
- & Fang Yuan
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Article
| Open AccessSelective haematological cancer eradication with preserved haematopoiesis
An antibody–drug conjugate that targets the pan-haematopoietic marker CD45 combined with transplanted stem cells engineered to be shielded from it can eradicate leukaemic cells while preserving haematopoiesis.
- Simon Garaudé
- , Romina Marone
- & Lukas T. Jeker
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World View |
Why role-playing games can spur climate action
Solving problems in a safe, collaborative environment can help us think out of the box and build empathy — crucial skills in a warming world.
- Sam Illingworth
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News & Views |
Neural pathways for reward and relief promote fentanyl addiction
Neuroscientists find that two distinct neural pathways are responsible for the addictive properties of the opioid fentanyl: one mediates reward, the other promotes the seeking of relief from symptoms of withdrawal.
- Markus Heilig
- & Michele Petrella
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Research Briefing |
How the same brain cells can represent both the perception and memory of faces
Long-term memories are thought to be represented by the same brain areas as those that encode sensory stimuli, but the mechanisms remain unclear. A study that recorded neural activity from face-selective regions of the macaque brain found that these regions represent familiar faces using a neural code that is distinct from the one for sensory representation.
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Article
| Open AccessMapping model units to visual neurons reveals population code for social behaviour
A deep neural network with ‘knockout training’ is used to model sensorimotor transformations and neural perturbations of male Drosophila melanogaster during visually guided social behaviour and provides predictions and insights into relationships between stimuli, neurons and behaviour.
- Benjamin R. Cowley
- , Adam J. Calhoun
- & Mala Murthy
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Article
| Open AccessLife-cycle-coupled evolution of mitosis in close relatives of animals
We analyse cell division in ichthyosporeans and find that multinucleated life cycles favour the evolution of closed mitosis, in which the cell constructs a spindle within an intact nucleus.
- Hiral Shah
- , Marine Olivetta
- & Gautam Dey
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Article
| Open AccessNatural proteome diversity links aneuploidy tolerance to protein turnover
Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.
- Julia Muenzner
- , Pauline Trébulle
- & Markus Ralser
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Article
| Open AccessKainate receptor channel opening and gating mechanism
Structures of the kainate receptor GluK2 with and without concanavilin A and BPAM344 show how these ligands modulate channel activity and reveal the molecular basis of kainate receptor gating.
- Shanti Pal Gangwar
- , Maria V. Yelshanskaya
- & Alexander I. Sobolevsky
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Article
| Open AccessMolecular mechanism of choline and ethanolamine transport in humans
Structural analysis of the human choline and ethanolamine transporters FLVCR1 and FLVCR2 clarifies the mechanisms of transport, the conformational dynamics of these proteins and the disease-associated mutations that interfere with these processes.
- Keiken Ri
- , Tsai-Hsuan Weng
- & Schara Safarian
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News |
China’s ChatGPT: what a boom in Chinese chatbots means for AI
ChatGLM is one of hundreds of AI language models being developed for the Chinese language. It comes close to ChatGPT on many measures, say its creators.
- Celeste Biever
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Article
| Open AccessDistinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement
Experiments using fentanyl treatment of mice show that µ-opioid receptors mediate positive reinforcement in the ventral tegmental area and negative reinforcement in central amygdala, thereby identifying the circuits that lead to opioid addiction.
- Fabrice Chaudun
- , Laurena Python
- & Christian Lüscher
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Article
| Open AccessStructural insights into the cross-exon to cross-intron spliceosome switch
Cryo-electron microscopy structures of cross-exon pre-B and B-like complexes contribute new insights into the molecular mechanisms that mediate the switch from a cross-exon to a cross-intron organized spliceosome.
- Zhenwei Zhang
- , Vinay Kumar
- & Reinhard Lührmann
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Article
| Open AccessAcquisition of epithelial plasticity in human chronic liver disease
Single-cell RNA sequencing and 3D imaging have revealed the cellular changes and structural reorganization that occur during the progression of human chronic liver disease and as the liver attempts to regenerate.
- Christopher Gribben
- , Vasileios Galanakis
- & Ludovic Vallier
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Article |
Covalent targeted radioligands potentiate radionuclide therapy
Radiopharmaceuticals engineered with click chemistry to selectively bind to tumour-specific proteins can be used to successfully target tumour cells, boosting the pharmacokinetics of radionuclide therapy and improving tumour regression.
- Xi-Yang Cui
- , Zhu Li
- & Zhibo Liu
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Correspondence |
Trials that infected people with common colds can inform today’s COVID-19 challenge trials
- Jonathan Ewbank
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News & Views |
Save the forest to save the tiger — why vegetation conservation matters
The Royal Botanic Gardens, Kew, emphasizes the importance of conserving wild plant species, plus a wonderstruck sky-watcher spots a brilliant meteor, in the weekly dip into Nature’s archive.
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News |
Lab-grown sperm and eggs: ‘epigenetic’ reset in human cells paves the way
Technique wipes away tags on DNA that must be reprogrammed during development of reproductive cells.
- Heidi Ledford
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Editorial |
A global pandemic treaty is in sight: don’t scupper it
Millions of people died of COVID-19 because the fundamental principle of equity between nations was ignored during the outbreak. That must not be allowed to happen again.
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News |
First ‘bilingual’ brain-reading device decodes Spanish and English words
Artificial-intelligence system allows a man who cannot speak coherently to have a conversation in the language of his choice.
- Amanda Heidt
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Article |
In vitro reconstitution of epigenetic reprogramming in the human germ line
- Yusuke Murase
- , Ryuta Yokogawa
- & Mitinori Saitou
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News |
The origin of the cockroach: how a notorious pest conquered the world
Genomic analysis suggests the common kitchen vermin spread from Europe to the world. But it wasn’t originally found in Europe.
- Bianca Nogrady
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Technology Feature |
DeepLabCut: the motion-tracking tool that went viral
Mackenzie and Alexander Mathis were still early in their careers when their software created a sensation. Now they’re using it to support other young scientists.
- Jyoti Madhusoodanan
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Article |
A deep catalogue of protein-coding variation in 983,578 individuals
- Kathie Y. Sun
- , Xiaodong Bai
- & Suganthi Balasubramanian
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News |
China's Yangtze fish-rescue plan is a failure, study says
Researchers have debated the best management plan for highly endangered fish species since the 1980s.
- Xiaoying You
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News |
Pig-organ transplants: what three human recipients have taught scientists
As researchers mark the loss of the first living recipient of a pig kidney, they share what they’ve learnt about xenotransplantation.
- Max Kozlov
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News |
Could bird flu in cows lead to a human outbreak? Slow response worries scientists
The H5N1 virus is a long way from becoming adapted to humans, but limited testing and tracking mean we could miss danger signs.
- Smriti Mallapaty
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Obituary |
Daniel Dennett obituary: ‘New atheism’ philosopher who sparked debate on consciousness
Cognitive scientist who boldly explored free will, the human mind and AI, and rejected the existence of God.
- Liad Mudrik
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News |
Gut microbes linked to fatty diet drive tumour growth
Scientists know there is a link between obesity and some cancers. A study in mice and people suggests why that might be.
- Gillian Dohrn
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News |
US halts funding to controversial virus-hunting group: what researchers think
Some scientists think the decision regarding EcoHealth Alliance is fair; others say it might negatively affect virus surveillance.
- Mariana Lenharo
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Article |
Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines
- Chieh-Yu Liang
- , Saravanan Raju
- & Michael S. Diamond
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News Feature |
How to kill the ‘zombie’ cells that make you age
Researchers are using new molecules, engineered immune cells and gene therapy to kill senescent cells and treat age-related diseases.
- Carissa Wong
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News & Views |
Dual-action obesity drug rewires brain circuits for appetite
A two-in-one drug that modulates neural pathways involved in appetite and reward might prove to be more effective and longer lasting than current weight-loss drugs on the market.
- Tyler M. Cook
- & Darleen Sandoval
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News & Views |
Parental-care puzzle in mice solved by thinking outside the brain
Both parents of oldfield mice care for offspring, whereas in deer mice, mothers usually care for pups. The discovery of a type of adrenal-gland cell that is present in oldfield mice but not in deer mice helps to explain the difference.
- Jessica Tollkuhn
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Nature Podcast |
Lizard-inspired building design could save lives
How knocking down a building helped researchers design a safer structure, and a sustainable 3D printing resin made from a bodybuilding supplement.
- Benjamin Thompson
- & Elizabeth Gibney
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Editorial |
Forestry social science is failing the needs of the people who need it most
Rich nations’ fixation on forests as climate offsets has resulted in the needs of those who live in or make a living from these resources being ignored. A broader view and more collaboration between disciplines is required.
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Article |
Evolution of a novel adrenal cell type that promotes parental care
The adrenal gland of the oldfield mouse (Peromyscus polionotus) has a recently evolved cell type that promotes monogamous-typical parenting behaviour and is not present in closely related species.
- Natalie Niepoth
- , Jennifer R. Merritt
- & Andres Bendesky
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Article
| Open AccessThe rise of baobab trees in Madagascar
We carried out genomic and ecological analyses of all eight extant baobab species, providing insights into their evolutionary history and recommendations for conservation efforts.
- Jun-Nan Wan
- , Sheng-Wei Wang
- & Qing-Feng Wang
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Article |
Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice
The ubiquitin E3 ligase OsCIE1 acts as a brake to inhibit OsCERK1 during homeostasis; this brake is released after chitin stimulation.
- Gang Wang
- , Xi Chen
- & Ertao Wang
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Review Article |
Decoding the interplay between genetic and non-genetic drivers of metastasis
This Review discusses the importance of genetic and non-genetic reprogramming events during the metastatic cascade.
- Panagiotis Karras
- , James R. M. Black
- & Jean-Christophe Marine
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Article
| Open AccessThe temperature sensor TWA1 is required for thermotolerance in Arabidopsis
TWA1 is a temperature-sensing transcriptional co-regulator that is needed for basal and acquired thermotolerance in Arabidopsis thaliana.
- Lisa Bohn
- , Jin Huang
- & Erwin Grill
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News |
Experimental obesity drug packs double punch to reduce weight
Test of weight-loss candidate in mice shows that there is still room for improvement in a burgeoning field.
- Asher Mullard
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Article
| Open AccessTemporal multiplexing of perception and memory codes in IT cortex
We examined how familiar faces are encoded in inferotemporal, perirhinal and temporal pole face patches, and found that relative response magnitude to familiar versus unfamiliar faces was not a stable indicator of familiarity in any patch.
- Liang She
- , Marcus K. Benna
- & Doris Y. Tsao
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Article
| Open AccessPhysiological temperature drives TRPM4 ligand recognition and gating
A temperature-dependent Ca2+-binding site in the intracellular domain of TRPM4 is essential for TRPM4 function in physiological contexts.
- Jinhong Hu
- , Sung Jin Park
- & Wei Lü
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