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Letter |
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
The enzyme eNOS is crucial for regulating vascular function as it can produce both the vasodilator nitric oxide and the vasoconstrictor superoxide. Here it is shown that a modification associated with oxidant stress, S-glutathionylation, switches the enzyme from forming nitric oxide to forming superoxide. In hypertensive vessels, S-glutathionylation of eNOS is increased and this is associated with impaired endothelium-dependent vasodilation.
- Chun-An Chen
- , Tse-Yao Wang
- & Jay L. Zweier