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| Open AccessCombined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice
- Catherine M. Sampson
- , Andrea L. Dimet
- & Stanley J. Watowich
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| Open AccessAntagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic
- Ana C. Henriques
- , Patrícia M. A. Silva
- & Hassan Bousbaa
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| Open AccessLabel-free spectral imaging to study drug distribution and metabolism in single living cells
- Qamar A. Alshammari
- , Rajasekharreddy Pala
- & Surya M. Nauli
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| Open AccessAntifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models
- Benjamin Bonnard
- , Ernesto Martínez-Martínez
- & Frédéric Jaisser
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| Open AccessA high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics
- Anthony D. Verderosa
- , Rabeb Dhouib
- & Makrina Totsika
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| Open AccessMycobacterium tuberculosis Rv3160c is a TetR-like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c
- Hasan Tükenmez
- , Souvik Sarkar
- & Christer Larsson
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| Open Access(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages
- Chandra L. Shrestha
- , Shuzhong Zhang
- & Benjamin T. Kopp
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| Open AccessPMO-based let-7c site blocking oligonucleotide (SBO) mediated utrophin upregulation in mdx mice, a therapeutic approach for Duchenne muscular dystrophy (DMD)
- Kasturi Sengupta
- , Emanuele Loro
- & Tejvir S. Khurana
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| Open AccessAnti-apoptotic peptide for long term cardioprotection in a mouse model of myocardial ischemia–reperfusion injury
- Aurélie Covinhes
- , Laura Gallot
- & Stéphanie Barrère-Lemaire
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| Open AccessA network pharmacology-based approach to explore potential targets of Caesalpinia pulcherima: an updated prototype in drug discovery
- Nikhil S. Sakle
- , Shweta A. More
- & Santosh N. Mokale
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| Open AccessSoticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice
- Toshiya Nishi
- , Shinichi Kondo
- & Tatsuki Koike
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| Open AccessFFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells
- Estela Lorza-Gil
- , Gabriele Kaiser
- & Susanne Ullrich
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| Open AccessPKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor
- Tigist Y. Tamir
- , David H. Drewry
- & Alison D. Axtman
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| Open AccessIdentification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae
- Tahl Zimmerman
- , Valerie Chasten
- & Salam A. Ibrahim
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| Open AccessA membrane transporter determines the spectrum of activity of a potent platinum–acridine hybrid anticancer agent
- Xiyuan Yao
- , Noah H. Watkins
- & Ulrich Bierbach
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Article
| Open AccessInhibition of acetyl-CoA carboxylase by spirotetramat causes growth arrest and lipid depletion in nematodes
- Philipp Gutbrod
- , Katharina Gutbrod
- & Florian M. W. Grundler
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| Open AccessBAFF attenuates oxidative stress-induced cell death by the regulation of mitochondria membrane potential via Syk activation in WiL2-NS B lymphoblasts
- Sojin Park
- , Ju-Won Jang
- & Eun-Yi Moon
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| Open AccessEvaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice
- Charles R. Goodlett
- , Megan Stringer
- & Randall J. Roper
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| Open AccessImpact of chronic HCV treatment on quality of life of patients with metabolic disorders in context of immunological disturbances
- Agata Kierepa
- , Aleksandra Witkowska
- & Iwona Mozer-Lisewska
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| Open AccessAspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
- Lennart Brewitz
- , Anthony Tumber
- & Christopher J. Schofield
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| Open AccessStructural dynamic studies on identification of EGCG analogues for the inhibition of Human Papillomavirus E7
- Murali Aarthy
- , Umesh Panwar
- & Sanjeev Kumar Singh
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| Open AccessThe aryl hydrocarbon receptor pathway controls matrix metalloproteinase-1 and collagen levels in human orbital fibroblasts
- Elisa Roztocil
- , Christine L. Hammond
- & Collynn F. Woeller
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| Open AccessSmall molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells
- Caroline Wiser
- , Byungil Kim
- & Manuel Ascano
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| Open AccessIn-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o
- Leonard Blum
- , Sheraz Gul
- & Susanne Schiffmann
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| Open AccessRegulation of left atrial fibrosis induced by mitral regurgitation by SIRT1
- Dong Zhang
- , Bo Li
- & Yue Tang
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| Open AccessAnti-CD81 antibodies reduce migration of activated T lymphocytes and attenuate mouse experimental colitis
- Takuya Hasezaki
- , Tadahiko Yoshima
- & Yukiko Mine
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| Open AccessSprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo
- D. Reker
- , A. S. Siebuhr
- & A. C. Bay-Jensen
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| Open AccessSelective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism
- Nathan J. Schauer
- , Xiaoxi Liu
- & Sara J. Buhrlage
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| Open Access[18F]SPA-RQ/PET Study of NK1 receptors in the Whole Body of Guinea Pig and Rat
- Tove J. Grönroos
- , Sarita Forsback
- & Olof Solin
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| Open AccessGlycogen Synthase Kinase-3β Inhibition with 9-ING-41 Attenuates the Progression of Pulmonary Fibrosis
- Ann Jeffers
- , Wenyi Qin
- & Torry A. Tucker
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| Open AccessValidation of antibodies for the specific detection of human TRPA1
- H. S. Virk
- , M. Z. Rekas
- & P. Bradding
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| Open AccessChaperone Sigma1R mediates the neuroprotective action of afobazole in the 6-OHDA model of Parkinson’s disease
- Mikhail V. Voronin
- , Ilya A. Kadnikov
- & Sergey B. Seredenin
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| Open AccessDiscovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors
- Irina Kufareva
- , Benoit Bestgen
- & Ruben Abagyan
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| Open AccessThe MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway
- Nadia Gul
- , Joakim Karlsson
- & Per Lindahl
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| Open AccessInhibition of Kirsten-Ras reduces fibrosis and protects against renal dysfunction in a mouse model of chronic folic acid nephropathy
- Lucy J. Newbury
- , Jui-Hui Wang
- & Claire C. Sharpe
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| Open AccessEpitope Mapping by NMR of a Novel Anti-Aβ Antibody (STAB-MAb)
- Adrián Posado-Fernández
- , Cláudia F. Afonso
- & Eurico J. Cabrita
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| Open AccessAn empirical assessment of research practices across 163 clinical trials of tumor-bearing companion dogs
- Yuan Jin Tan
- , Ryan J. Crowley
- & John P. A. Ioannidis
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| Open AccessThe TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids
- Sebastian Prill
- , Andrea Caddeo
- & Stefano Romeo
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| Open AccessAnti-cancer activity of the novel 2-hydroxydiarylamide derivatives IMD-0354 and KRT1853 through suppression of cancer cell invasion, proliferation, and survival mediated by TMPRSS4
- Solbi Kim
- , Dongjoon Ko
- & Semi Kim
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| Open AccessDifferential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes
- Mariana Cooke
- , Victoria Casado-Medrano
- & Marcelo G. Kazanietz
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| Open AccessAn in vivo wound healing model for the characterization of the angiogenic process and its modulation by pharmacological interventions
- Martin Karl Schneider
- , Horea-Ioan Ioanas
- & Markus Rudin
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| Open AccessMonocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation
- Yibing Wang
- , Rebecca Edelmayer
- & Steve McGaraughty
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| Open AccessChimeric NANOG repressors inhibit glioblastoma growth in vivo in a context-dependent manner
- Monika Kuciak
- , Christophe Mas
- & Ariel Ruiz i Altaba
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| Open AccessModeling ErbB2-p130Cas interaction to design new potential anticancer agents
- Andrea Costamagna
- , Matteo Rossi Sebastiano
- & Sara Cabodi
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| Open AccessNovel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity
- Aaron DeBono
- , David R. Thomas
- & David A. Jans
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| Open AccessOn-target and off-target effects of novel orthosteric and allosteric activators of GPR84
- Sarah J. Mancini
- , Zobaer Al Mahmud
- & Graeme Milligan
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| Open AccessDifferential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures
- Lizet M. van der Waals
- , Jamila Laoukili
- & Onno Kranenburg
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| Open AccessOff-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia
- Brent M. Kuenzi
- , Lily L. Remsing Rix
- & Uwe Rix
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| Open AccessA novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors
- Malini Menon
- , Richard Elliott
- & Christopher J. Lord