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Article
| Open AccessCD201+ fascia progenitors choreograph injury repair
Spatiotemporal regulation of wound healing in mice and humans occurs via retinoic acid and hypoxia signalling, which regulate the differentiation of CD201+ fibroblast progenitors into proinflammatory and myofibroblast states.
- Donovan Correa-Gallegos
- , Haifeng Ye
- & Yuval Rinkevich
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Article |
A multi-stem cell basis for craniosynostosis and calvarial mineralization
The calvarial stem cell niche is populated by a cathepsin K-expressing cell lineage and a newly identified discoidin domain-containing receptor 2-expressing lineage, both of which are required for proper calvarial mineralization.
- Seoyeon Bok
- , Alisha R. Yallowitz
- & Matthew B. Greenblatt
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Article |
Generation of 3D lacrimal gland organoids from human pluripotent stem cells
Organoids originating from human multipotent ocular surface epithelial stem cells are similar to native lacrimal glands and undergo functional maturation when transplanted adjacent to the eyes of recipient rats, developing lumina and producing tear-film proteins.
- Ryuhei Hayashi
- , Toru Okubo
- & Kohji Nishida
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Article |
An organoid-based organ-repurposing approach to treat short bowel syndrome
In a rat model of short bowel syndrome, transplantation of small intestinal organoids into the colon partially restores intestinal function and improves survival—a proof of principle that organoid transplantation might have therapeutic benefit.
- Shinya Sugimoto
- , Eiji Kobayashi
- & Toshiro Sato
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Article |
Nociceptive nerves regulate haematopoietic stem cell mobilization
Stimulation of pain-sensing neurons, which can be achieved in mice by the ingestion of capsaicin, promotes the migration of haematopoietic stem cells from the bone marrow into the blood.
- Xin Gao
- , Dachuan Zhang
- & Paul S. Frenette
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Article |
Somatic inflammatory gene mutations in human ulcerative colitis epithelium
Whole-exome sequencing of colon organoids derived from patients with ulcerative colitis identifies somatic mutations in components of the IL-17 signalling pathway, which may confer a growth advantage to cells under inflammatory conditions.
- Kosaku Nanki
- , Masayuki Fujii
- & Toshiro Sato
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Article |
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment
MLLT3 is identified as a crucial regulator of the self-renewal of human haematopoietic stem cells, and helps to maintain an active chromatin state in haematopoietic stem-cell regulatory genes during culture.
- Vincenzo Calvanese
- , Andrew T. Nguyen
- & Hanna K. A. Mikkola
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Letter |
Linking a cell-division gene and a suicide gene to define and improve cell therapy safety
Introduction of a suicide gene together with a linked cell-division gene to generate a safe-cell system enables the selective elimination of proliferating cells after cell transplantation in mouse models of cell therapy.
- Qin Liang
- , Claudio Monetti
- & Andras Nagy
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Letter |
Advanced maturation of human cardiac tissue grown from pluripotent stem cells
A tissue culture system that provides an increasing intensity of electromechanical stimulation over time enables an in vitro model of cardiac tissue derived from human induced pluripotent stem cells to develop many of the characteristics of adult cardiac tissue.
- Kacey Ronaldson-Bouchard
- , Stephen P. Ma
- & Gordana Vunjak-Novakovic
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Article |
Regeneration of the entire human epidermis using transgenic stem cells
Autologous transgenic epidermal stem cell cultures are used to reconstitute almost the entire epidermis of a patient with severe junctional epidermolysis bullosa.
- Tobias Hirsch
- , Tobias Rothoeft
- & Michele De Luca
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Letter |
A reversible haploid mouse embryonic stem cell biobank resource for functional genomics
The Haplobank contains over 100,000 individually reversibly mutagenized, barcoded, mouse embryonic cell lines; proof-of-principle experiments were used to search for genes that are required for rhinovirus infection and angiogenesis using forward and reverse genetic screens, respectively.
- Ulrich Elling
- , Reiner A. Wimmer
- & Josef M. Penninger
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Letter |
Comparative glycoproteomics of stem cells identifies new players in ricin toxicity
A novel quantitative approach to identify intact glycopeptides from comparative proteomic data sets, allowing inference of complex glycan structures and direct mapping of them to sites within the associated proteins at the proteome scale.
- Johannes Stadlmann
- , Jasmin Taubenschmid
- & Josef M. Penninger
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Article |
Conversion of adult endothelium to immunocompetent haematopoietic stem cells
The authors reprogram in vitro endothelial cells from adult mice into engraftable haematopoietic stem cells that display single-cell and multilineage properties, are capable of long-term self-renewal and can reconstitute T cell adaptive immune function.
- Raphael Lis
- , Charles C. Karrasch
- & Shahin Rafii
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Letter |
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
Allogenic induced pluripotent stem cell-derived cardiomyocytes transplanted directly into infarcted cynomolgus monkey hearts show electrical coupling with host cardiomyocytes improve cardiac contractile function after mild immunosuppression.
- Yuji Shiba
- , Toshihito Gomibuchi
- & Uichi Ikeda
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Letter |
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
The kidney arises from two types of progenitors; here, the signalling conditions that induce the production of collecting ducts and functional nephrons from human pluripotent stem cells are determined, and organoids that recapitulate the functional regionalization of the kidney are produced.
- Minoru Takasato
- , Pei X. Er
- & Melissa H. Little
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Spotlight |
Spotlight on Stem Cell Research
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Letter |
Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
Regeneration of the heart muscle after myocardial infarction with cardiomyocytes derived from human embryonic stem cells is demonstrated in non-human primates, with the grafts showing evidence of electromechanical coupling, although they were also associated with non-fatal arrhythmias.
- James J. H. Chong
- , Xiulan Yang
- & Charles E. Murry
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Letter |
Direct measurement of local oxygen concentration in the bone marrow of live animals
Here, using two-photon phosphorescence lifetime microscopy, the local oxygen tension in the bone marrow of live mice is found to be quite low, with spatiotemporal variations depending on the blood vessel type, distance to the endosteum, and changes in cellularity after stress.
- Joel A. Spencer
- , Francesca Ferraro
- & Charles P. Lin
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Article |
Arteriolar niches maintain haematopoietic stem cell quiescence
Immunofluorescence imaging and computational modelling are used to study the spatial distribution of different cell types within the haematopoietic stem cell (HSC) niche; findings show that quiescent HSCs associate specifically with small arterioles that are preferentially found in the endosteal bone marrow and are essential in maintaining this quiescence.
- Yuya Kunisaki
- , Ingmar Bruns
- & Paul S. Frenette
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Spotlight |
Spotlight on Stem Cell Research
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Inside View |
Inside View: Bettencourt Schueller Foundation
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Research Highlights |
Stem cells wrap neurons
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News |
Stem-cell fraud hits febrile field
After heart-treatment claims collapse, researchers caution against a rush to the clinic.
- David Cyranoski
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News |
Cell rewind wins medicine Nobel
Researchers awarded prestigious prize for their work on reprogramming mature cells to a pluripotent state.
- Alison Abbott
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Editorial |
Renewed vigour
Stem-cell researchers must engage with politicians to keep their work alive in Europe.
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News |
Rudimentary liver grown in vitro
Japanese scientists coax pluripotent cells to form functional liver tissue.
- David Cyranoski
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Spotlight |
Spotlight on Stem-Cell Research
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News |
South Korea steps up stem-cell work
Regenerative medicine gets cash boost but stricter regulations are needed to ensure safety.
- Soo Bin Park
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Research Highlights |
Patient-specific heart cells
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News |
China’s stem-cell rules go unheeded
Health ministry’s attempt at regulation has had little effect.
- David Cyranoski
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News |
Vatican calls off stem-cell conference
Embryonic-stem-cell researchers question sudden cancellation of annual meeting.
- Ewen Callaway
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Q&A |
Turning point: Sean Bendall
Following the ‘road not taken’ philosophy, stem-cell specialist earns award and start-up money.
- Virginia Gewin
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Outlook |
Q&A: Stemming the tide of misinformation
As director of outreach experiences at the Morgridge Institute for Research in Madison, Wisconsin, Nirupama Shevde spreads the word about stem cells. Nature Outlook finds out what she has to say.
- Nirupama Shevde
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Outlook |
Stem Cells: Flexible friends
Stem cells are powerful tools in biology and medicine. What can scientists do with these cells to exploit their incredible potential?
- Nirupama Shevde
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News |
Stem-cell agency faces budget dilemma
The California Institute for Regenerative Medicine plans for a future without state support.
- Erika Check Hayden
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News |
Candidates play to the right on science
Rivals for the Republican nomination laud research but take a hard line on embryonic stem cells and climate.
- Susan Young
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News Feature |
Stem-cell research: Never say die
With a history of public blunders, can Advanced Cell Technology make embryonic stem-cell therapies a reality?
- Corie Lok
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News Feature |
Stem cells: The cell division
Oliver Brüstle fought for more than a decade to pursue and patent human embryonic stem-cell research in Germany. Now his efforts have backfired.
- Alison Abbott
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News |
German science organizations slam European court over stem-cell ruling
European Court of Justice had no right to impose moral judgement on science, says influential group.
- Alison Abbott
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Comment |
Beyond HeLa cells
To find out what distinguishes one cell type from another, cell biologists must renounce popular cell lines, argue Anthony H. Hyman and Kai Simons.
- Anthony H. Hyman
- & Kai Simons
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News |
Stem-cell pioneer bows out
Geron halts first-of-its-kind clinical trial for spinal therapy.
- Monya Baker
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Research Highlights |
Breathing easier with stem cells
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News |
Cloned human embryo makes working stem cells
Researchers begin to identify past problems with cloning technique.
- David Cyranoski
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Editorial |
Safe, not secure
A legal victory for US stem-cell research will not end the uncertainty over this disputed field.
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News |
Court quashes stem-cell lawsuit
US judge throws out case meant to halt federal funding, but research remains vulnerable.
- Meredith Wadman
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Comment |
Regulate research at the animal–human interface
The time is right, says Martin Bobrow, to improve the governance of research involving animals that contain human genetic or cellular material.
- Martin Bobrow