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| Open AccessIdentification and structural characterization of small molecule inhibitors of PINK1
- Shafqat Rasool
- , Tara Shomali
- & Jean-François Trempe
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| Open AccessEffects of psychological stress on the emission of volatile organic compounds from the skin
- Géraldine Lucchi
- , Marine Crépin
- & Katell Vié
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| Open AccessA kinetic-based stopped-flow DPPH• method
- Lucrezia Angeli
- , Ksenia Morozova
- & Matteo Scampicchio
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| Open AccessMechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition
- Laurent Le Corre
- & Dominique Padovani
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| Open AccessModulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
- Frances M. Bashore
- , Ariana B. Marquez
- & Alison D. Axtman
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| Open AccessSynthesis and physicochemical characterization of acyl myricetins as potential anti-neuroexocytotic agents
- Sora Cho
- , Byoungjae Kong
- & Dae-Hyuk Kweon
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| Open AccessCombining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi
- Téo Hebra
- , Nicolas Pollet
- & Véronique Eparvier
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| Open AccessA new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation
- Deniz Cansen Kahraman
- , Ebru Bilget Guven
- & Rengul Cetin Atalay
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| Open AccessDevelopment of a novel light-up probe for detection of G-quadruplexes in stress granules
- Keisuke Iida
- , Natsumi Suzuki
- & Takayoshi Arai
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| Open AccessExamination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine
- Pavlína Hašková
- , Lenka Applová
- & Tomáš Šimůnek
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| Open AccessSubstrate-dependent modulation of the leukotriene A4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation
- Kyung Hyeon Lee
- , Nadia Fazal Ali
- & Mikell Paige
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Article
| Open AccessComprehensive metabolomics unveil the discriminatory metabolites of some Mediterranean Sea marine algae in relation to their cytotoxic activities
- Dina S. Ghallab
- , Eman Shawky
- & Mohamed M. Mohyeldin
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Article
| Open AccessA novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium
- Rune Slimestad
- , Bendik Auran Rathe
- & Torgils Fossen
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| Open AccessRational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons
- Alessandro Soloperto
- , Deborah Quaglio
- & Alberto Boffi
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Article
| Open AccessComprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay
- Alexander Medvedev
- , Matt Moeser
- & Sergei S. Makarov
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| Open AccessNon-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits
- Giacomo G. Rossetti
- , Marianna A. Ossorio
- & Thanos D. Halazonetis
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Article
| Open AccessTargeted isolation of photoactive pigments from mushrooms yielded a highly potent new photosensitizer: 7,7′-biphyscion
- Fabian Hammerle
- , Isabella Bingger
- & Bianka Siewert
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| Open AccessBreath biomarkers of insulin resistance in pre-diabetic Hispanic adolescents with obesity
- Mohammad S. Khan
- , Suzanne Cuda
- & Andrew C. Bishop
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Article
| Open AccessDNA binding by the antimalarial compound artemisinin
- Sladjana Slavkovic
- , Aron A. Shoara
- & Philip E. Johnson
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| Open AccessChemical strategies for triggering the immune response to the mycotoxin patulin
- Hadyn Duncan
- , Josep V. Mercader
- & Antonio Abad-Fuentes
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| Open AccessActivation of specific bitter taste receptors by olive oil phenolics and secoiridoids
- Meng Cui
- , Bohan Chen
- & Prokopios Magiatis
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| Open AccessComparison of bacteria disintegration methods and their influence on data analysis in metabolomics
- Karolina Anna Mielko
- , Sławomir Jan Jabłoński
- & Piotr Młynarz
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| Open AccessThe selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages
- Wenyun Zeng
- , Danbin Wu
- & Yijing Wang
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| Open AccessEffects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy
- Samantha T. Reyes
- , Robert M. J. Deacon
- & Frederick T. Chin
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| Open AccessSubstituted 1,2,3-triazoles: a new class of nitrification inhibitors
- Bethany I. Taggert
- , Charlie Walker
- & Uta Wille
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| Open AccessDevelopment and validation of HPLC-MS2 methodology for the accurate determination of C4–C8 B-type flavanols and procyanidins
- Ugo Bussy
- , Yusuf Olanrewaju
- & Catherine Kwik-Uribe
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| Open AccessIsolation and structure elucidation of pyridine alkaloids from the aerial parts of the Mongolian medicinal plant Caryopteris mongolica Bunge
- Dumaa Mishig
- , Margit Gruner
- & Hans-Joachim Knölker
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| Open AccessAcyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro
- Eva Doleželová
- , Tomáš Klejch
- & Alena Zíková
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| Open AccessIn silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin
- Sakshi Piplani
- , Puneet Kumar Singh
- & Nikolai Petrovsky
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Article
| Open AccessQuinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease
- Sohui Park
- , Hye Yun Kim
- & YoungSoo Kim
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| Open AccessA novel piperazine derivative that targets hepatitis B surface antigen effectively inhibits tenofovir resistant hepatitis B virus
- S. Kiruthika
- , Ruchika Bhat
- & B. Jayaram
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Article
| Open AccessZinc oxide nanoparticles improve testicular steroidogenesis machinery dysfunction in benzo[α]pyrene-challenged rats
- Niveen M. Daoud
- , Mohamed S. Aly
- & Naglaa A. Ali
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| Open AccessSmall molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers
- Martina Meßner
- , Melanie M. Mandl
- & Johanna Pachmayr
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| Open AccessA survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics
- Jessica Knox
- , Nicolas Joly
- & Peter J. Roy
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| Open AccessIn silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer
- Z. Ping Lin
- , Nour N. Al Zouabi
- & Elena S. Ratner
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| Open AccessIdentification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2
- Ewelina Weglarz-Tomczak
- , Jakub M. Tomczak
- & Stanley Brul
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| Open AccessTerroir and vintage discrimination of Malbec wines based on phenolic composition across multiple sites in Mendoza, Argentina
- Roy Urvieta
- , Gregory Jones
- & Ariel Fontana
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| Open AccessBreath can discriminate tuberculosis from other lower respiratory illness in children
- Carly A. Bobak
- , Lili Kang
- & Jane E. Hill
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| Open AccessSalicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations
- Karsten Burkert
- , Hadiseh Taheri
- & Tomo Šarić
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| Open AccessEnzyme and lateral flow monoclonal antibody-based immunoassays to simultaneously determine spirotetramat and spirotetramat-enol in foodstuffs
- Ramón E. Cevallos-Cedeño
- , Consuelo Agulló
- & Josep V. Mercader
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| Open AccessRetrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models
- Vishal B. Siramshetty
- , Pranav Shah
- & Xin Xu
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| Open AccessSynthesis and initial screening of lactate dehydrogenase inhibitor activity of 1,3-benzodioxole derivatives
- Dicky Annas
- , Se-Yun Cheon
- & Kang Hyun Park
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Article
| Open AccessDiversity of secoiridoid glycosides in leaves of UK and Danish ash provide new insight for ash dieback management
- John D. Sidda
- , Lijiang Song
- & Murray Grant
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| Open AccessSynthesis of two new lipid mediators from docosahexaenoic acid by combinatorial catalysis involving enzymatic and chemical reaction
- Jong-Jae Yi
- , Sun-Yeon Heo
- & Jeong-Woo Seo
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| Open AccessOxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide
- Radosław Michalski
- , David Thiebaut
- & Adam Sikora
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| Open AccessSimulations on the dual effects of flavonoids as suppressors of Aβ42 fibrillogenesis and destabilizers of mature fibrils
- Sahar Andarzi Gargari
- & Abolfazl Barzegar
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| Open AccessBardoxolone conjugation enables targeted protein degradation of BRD4
- Bingqi Tong
- , Mai Luo
- & Daniel K. Nomura
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| Open AccessPentagalloyl glucose from Schinus terebinthifolia inhibits growth of carbapenem-resistant Acinetobacter baumannii
- Micah Dettweiler
- , Lewis Marquez
- & Cassandra L. Quave
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| Open AccessEffects of time and temperature during melanging on the volatile profile of dark chocolate
- Caitlin Clark
- , Harmonie M. Bettenhausen
- & Martha Stone