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| Open AccessTopical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis
Scars are a significant problem caused by excess collagen in the skin. Here the authors develop a topical drug that reduces collagen stability and leads to improved scar appearance and stiffness in preclinical models.
- Nutan Chaudhari
- , Alison D. Findlay
- & Mark W. Fear
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| Open AccessInjury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin
Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinated cell migration that drives extensive scar formation of deep wounds.
- Dongsheng Jiang
- , Simon Christ
- & Yuval Rinkevich
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Article
| Open AccessSingle cell transcriptomics of human epidermis identifies basal stem cell transition states
The mechanisms regulating stem cells to give rise to human interfollicular epidermis are unclear. Here, the authors use single cell RNA sequencing to identify heterogeneity within the human neonatal interfollicular epidermis and distinct spatial positioning of at least four basal stem cell populations.
- Shuxiong Wang
- , Michael L. Drummond
- & Scott X. Atwood
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| Open AccessNoncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
During wound induced hair follicle neogenesis (WIHN), stem cells regenerate hair follicles but how this arises is unclear. Here, the authors show that self-noncoding dsRNA activates the antiviral receptor TLR3 to induce intrinsic retinoic acid, which stimulates WIHN in mice, and in isolated human keratinocyte cells.
- Dongwon Kim
- , Ruosi Chen
- & Luis A. Garza
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| Open AccessTissue engineering of human hair follicles using a biomimetic developmental approach
Human skin constructs hold potential for regenerative medicine, but the incorporation of hair follicles into such constructs is a challenge. Here, the authors use 3D printed molds to pattern hair follicle cell types in a physiological organization, and achieve human hair growth on the back of a mouse.
- Hasan Erbil Abaci
- , Abigail Coffman
- & Angela M. Christiano
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| Open AccessThe RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
The integrity of the stratified epithelia relies on controlled cell turnover but it is unclear how mRNA binding proteins regulates this. Here, the authors show that the RNA binding protein Y-box binding protein-1 translationally represses cytokines, so preventing senescence and maintaining epidermal homeostasis.
- Eunjeong Kwon
- , Kristina Todorova
- & Anna Mandinova
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Article
| Open AccessPNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis
Loss-of-function mutations inPNPLA1, a gene encoding an enzyme with unknown function, cause dry and scaling skin in humans. Using mouse models with PNPLA1 deficiency, the authors show that PNPLA1 participates in the biosynthesis of acylceramide, a lipid component essential for skin barrier function.
- Tetsuya Hirabayashi
- , Tatsuki Anjo
- & Makoto Murakami