Refractive errors articles within Nature Communications

Featured

• Article
  10 October 2022 | Open Access

  Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes

  he underlying mechanism of myopic axial elongation of the eyes has long been unknown. Here, the authors show that endoplasmic reticulum stress in the sclera and its sensor proteins, PERK and ATF6, are involved in myopic axial elongation

  • Shin-ichi Ikeda
  • , Toshihide Kurihara
  •  & Kazuo Tsubota

• Article
  08 April 2021 | Open Access

  Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia

  High myopia is associated with lens changes, but the underlying mechanisms are unclear. Here, the authors show increased equatorial diameter of the lens in subjects affected by high myopia, and find that these changes are associated with an increase in crystallin expression driven by the transcription factor MAF and TGF-β1 signaling.

  • Xiangjia Zhu
  • , Yu Du
  •  & Yi Lu

• Article
  03 May 2018 | Open Access

  CCDC102B confers risk of low vision and blindness in high myopia

  Myopic maculopathy is a complication of myopia that often progresses to blindness. Here, in a genome-wide association study, Hosoda et al. find that rs11873439 intronic to CCDC102B is associated with myopic maculopathy, but not with myopia, thus representing a risk factor independent of myopia.

  • Yoshikatsu Hosoda
  • , Munemitsu Yoshikawa
  •  & Kenji Yamashiro

• Article
  06 April 2016 | Open Access

  Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error

  This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.

  • Qiao Fan
  • , Virginie J. M. Verhoeven
  •  & Kari Matti Mäkelä

• Article | 31 March 2015

  Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

  Myopia is a significant and increasing public health concern. Here Miyake et al. conduct a genome-wide association study and identify WNT7Bas a susceptibility gene across different ethnic groups, suggesting a possible role in the development of myopia.

  • Masahiro Miyake
  • , Kenji Yamashiro
  •  & Nagahisa Yoshimura