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| Open AccessImmunoinformatics design of a structural proteins driven multi-epitope candidate vaccine against different SARS-CoV-2 variants based on fynomer
- Javad Sarvmeili
- , Bahram Baghban Kohnehrouz
- & Hamideh Ofoghi
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| Open AccessThe role of the correlated motion(s) of the chromophore in photoswitching of green and red forms of the photoconvertible fluorescent protein mSAASoti
- Alexandra V. Gavshina
- , Ilya D. Solovyev
- & Alexander P. Savitsky
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| Open AccessImmunoinformatics and computational approaches driven designing a novel vaccine candidate against Powassan virus
- Truc Ly Nguyen
- & Heebal Kim
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| Open AccessSynthetic receptor scaffolds significantly affect the efficiency of cell fate signals
- Kirato Umene
- & Masahiro Kawahara
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| Open AccessImmunoinformatics-guided approach for designing a pan-proteome multi-epitope subunit vaccine against African swine fever virus
- Alea Maurice Simbulan
- , Edward C. Banico
- & Fredmoore L. Orosco
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| Open AccessTwo-substrate enzyme engineering using small libraries that combine the substrate preferences from two different variant lineages
- Arka Mukhopadhyay
- , Kersti Karu
- & Paul A. Dalby
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| Open AccessExtensive antibody search with whole spectrum black-box optimization
- Andrejs Tučs
- , Tomoyuki Ito
- & Koji Tsuda
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| Open AccessComparative analysis of reconstructed ancestral proteins with their extant counterparts suggests primitive life had an alkaline habitat
- Takayuki Fujikawa
- , Takahiro Sasamoto
- & Satoshi Akanuma
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| Open AccessSolving the mystery of the FMC63-CD19 affinity
- Jacqueline Seigner
- , Charlotte U. Zajc
- & Michael W. Traxlmayr
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| Open AccessTesting a vaccine candidate against Hepatitis C virus designed by combinatorial optimization
- Iker Malaina
- , Luis Martinez
- & Carmen Alvarez-Dominguez
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| Open AccessHigh-throughput analysis system of interaction kinetics for data-driven antibody design
- Ryo Matsunaga
- , Kan Ujiie
- & Kouhei Tsumoto
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| Open AccessEngineering and design of promising T-cell-based multi-epitope vaccine candidates against leishmaniasis
- Esmaeil Roohparvar Basmenj
- , Mahshid Arastonejad
- & Hamid Irannejad
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| Open AccessTailoring FPOX enzymes for enhanced stability and expanded substrate recognition
- Hajar Estiri
- , Shapla Bhattacharya
- & Alfonso Gautieri
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| Open AccessRecovery of the histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selection
- Ayami Watanabe
- , Ami Nakajima
- & Mitsunori Shiroishi
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| Open AccessPhenotypic screening of signaling motifs that efficiently induce cell proliferation
- Kirato Umene
- , Teruyuki Nagamune
- & Masahiro Kawahara
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| Open AccessComputational redesign of Beta-27 Fab with substantially better predicted binding affinity to the SARS-CoV-2 Omicron variant than human ACE2 receptor
- Wantanee Treewattanawong
- , Thassanai Sitthiyotha
- & Surasak Chunsrivirot
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| Open AccessA probabilistic view of protein stability, conformational specificity, and design
- Jacob A. Stern
- , Tyler J. Free
- & Dennis Della Corte
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| Open AccessValproate regulates inositol synthesis by reducing expression of myo-inositol-3-phosphate synthase
- Kendall C. Case
- , Rachel J. Beltman
- & Miriam L. Greenberg
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| Open AccessDeveloping a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy
- Noam Tzuri
- , Ksenia M. Yegodayev
- & Niv Papo
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| Open AccessInvestigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein–protein interactions
- Gurjeet Kaur
- , Manisha Prajapat
- & Bikash Medhi
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| Open AccessRational peptide design for inhibition of the KIX–MLL interaction
- Nao Sato
- , Shunji Suetaka
- & Munehito Arai
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| Open AccessIncreasing the melting temperature of VHH with the in silico free energy score
- Yusuke Tomimoto
- , Rika Yamazaki
- & Hiroki Shirai
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| Open AccessIn silico design of a polypeptide as a vaccine candidate against ascariasis
- Francisco M. D. Evangelista
- , Arnoud H. M. van Vliet
- & Martha Betson
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| Open AccessIn silico protein engineering shows that novel mutations affecting NAD+ binding sites may improve phosphite dehydrogenase stability and activity
- Soukayna Baammi
- , Rachid Daoud
- & Achraf El Allali
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| Open AccessA highly sensitive NanoLuc-based protease biosensor for detecting apoptosis and SARS-CoV-2 infection
- Masashi Arakawa
- , Akiho Yoshida
- & Eiji Morita
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| Open AccessExperimental–theoretical study of laccase as a detoxifier of aflatoxins
- Marco Zaccaria
- , William Dawson
- & Babak Momeni
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| Open AccessGeneration of bright autobioluminescent bacteria by chromosomal integration of the improved lux operon ilux2
- Carola Gregor
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| Open AccessA growth-based platform for detecting domain–peptide interactions in the cytoplasm of mammalian cells
- Yosuke Kimura
- , Daiki Kashima
- & Masahiro Kawahara
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| Open AccessDirected evolution for soluble and active periplasmic expression of bovine enterokinase in Escherichia coli
- Weiluo Lee
- , Subhas Pradhan
- & Paul A. Dalby
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| Open AccessA novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron
- Iam Palatnik-de-Sousa
- , Zachary S. Wallace
- & Clarisa Beatriz Palatnik-de-Sousa
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| Open AccessPrediction of the structural interface between fibroblast growth factor23 and Burosumab using alanine scanning and molecular docking
- Karnpob Kanhasut
- , Kannan Tharakaraman
- & Ram Sasisekharan
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| Open AccessIdentification and construction of a multi-epitopes vaccine design against Klebsiella aerogenes: molecular modeling study
- Sami I. Alzarea
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| Open AccessComprehensive analysis of transglutaminase substrate preference by cDNA display coupled with next-generation sequencing and bioinformatics
- Jasmina Damnjanović
- , Nana Odake
- & Hideo Nakano
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| Open AccessA multifaceted strategy to improve recombinant expression and structural characterisation of a Trypanosoma invariant surface protein
- Hagen Sülzen
- , Jitka Votrubova
- & Sebastian Zoll
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| Open AccessAntibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens
- Hung-Pin Peng
- , Hung-Ju Hsu
- & An-Suei Yang
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| Open AccessTowards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases
- Souad Diana Tork
- , Mădălina Elena Moisă
- & László Csaba Bencze
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| Open AccessAssessing sequence-based protein–protein interaction predictors for use in therapeutic peptide engineering
- François Charih
- , Kyle K. Biggar
- & James R. Green
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| Open AccessIn silico design and analyses of a multi-epitope vaccine against Crimean-Congo hemorrhagic fever virus through reverse vaccinology and immunoinformatics approaches
- Akinyemi Ademola Omoniyi
- , Samuel Sunday Adebisi
- & Jens Randel Nyengaard
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| Open AccessFirst biphotochromic fluorescent protein moxSAASoti stabilized for oxidizing environment
- N. K. Marynich
- , M. G. Khrenova
- & A. P. Savitsky
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| Open AccessEffect of non-repetitive linker on in vitro and in vivo properties of an anti-VEGF scFv
- Merve Arslan
- , Murat Karadag
- & Sibel Kalyoncu
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| Open AccessA red fluorescent protein with improved monomericity enables ratiometric voltage imaging with ASAP3
- Benjamin B. Kim
- , Haodi Wu
- & Michael Z. Lin
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| Open AccessTherapeutic enzyme engineering using a generative neural network
- Andrew Giessel
- , Athanasios Dousis
- & Stuart Licht
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| Open AccessRational design of a helical peptide inhibitor targeting c-Myb–KIX interaction
- Shunji Suetaka
- , Yoshiki Oka
- & Munehito Arai
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| Open AccessComputational redesign of Fab CC12.3 with substantially better predicted binding affinity to SARS-CoV-2 than human ACE2 receptor
- Wantanee Treewattanawong
- , Thassanai Sitthiyotha
- & Surasak Chunsrivirot
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| Open AccessAntibody-guided design and identification of CD25-binding small antibody mimetics using mammalian cell surface display
- Kyra See
- , Tetsuya Kadonosono
- & Shinae Kizaka-Kondoh
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| Open AccessRedesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences
- Christopher R. Corbeil
- , Mahder Seifu Manenda
- & Enrico O. Purisima
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| Open AccessDelicate balance among thermal stability, binding affinity, and conformational space explored by single-domain VHH antibodies
- Emina Ikeuchi
- , Daisuke Kuroda
- & Kouhei Tsumoto
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| Open AccessEnzyme modification using mutation site prediction method for enhancing the regioselectivity of substrate reaction sites
- Jinzen Ikebe
- , Munenori Suzuki
- & Tomoshi Kameda
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| Open AccessA bimolecular fluorescence complementation flow cytometry screen for membrane protein interactions
- Florian Schmitz
- , Jessica Glas
- & Kristina Hedfalk