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| Open AccessQuantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
- Chenyan Zhao
- , Anders N. Kristoffersson
- & Lena E. Friberg
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| Open AccessIn-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells
- Sean N. Avedissian
- , Johid R. Malik
- & Courtney V. Fletcher
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| Open AccessDevelopment of extended pharmacokinetic models for propofol based on measured blood and brain concentrations
- Masayoshi Kawata
- , Atsushi Yonezawa
- & Yoshiki Arakawa
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| Open AccessIn vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway
- Shaimaa E. Diab
- , Nourhan A. Tayea
- & Zakia A. Olama
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| Open Access1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors
- Maurício T. Tavares
- , Arne Krüger
- & Roberto Parise-Filho
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| Open AccessReproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19
- Rob C. van Wijk
- , Laurynas Mockeliunas
- & Ulrika S. H. Simonsson
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| Open AccessPhysiologically-based pharmacokinetic modeling for optimal dosage prediction of olaparib when co-administered with CYP3A4 modulators and in patients with hepatic/renal impairment
- Dongmei Gao
- , Guopeng Wang
- & Jiawei Ren
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| Open AccessAdapting physiologically-based pharmacokinetic models for machine learning applications
- Sohaib Habiballah
- & Brad Reisfeld
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| Open AccessEvaluation and comparison of pharmacokinetic profiles and safety of two extended-release buprenorphine formulations in common marmosets (Callithrix jacchus)
- Niora J. Fabian
- , Anthony J. Mannion
- & Jennifer L. Haupt
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| Open AccessForensic toxicokinetics of difenidol hydrochloride in vivo verified by practical lethal cases
- Weifen Niu
- , Tongxi Ren
- & Keming Yun
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| Open AccessPharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides
- L. Reveret
- , M. Leclerc
- & F. Calon
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| Open AccessAssessing the impact of protonating acid combinations in e-cigarette liquids: a randomised, crossover study on nicotine pharmacokinetics
- Justin Frosina
- , Michael McEwan
- & George Hardie
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| Open AccessTranscranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model
- Evgenii Kim
- , Hyun-Chul Kim
- & Wonhye Lee
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| Open AccessApplication of a physiologically based pharmacokinetic model in predicting captopril disposition in children with chronic kidney disease
- Sundus Khalid
- , Muhammad Fawad Rasool
- & Faleh Alqahtani
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| Open AccessA validated LC–MS/MS method for clinical pharmacokinetics and presumptive phase II metabolic pathways following oral administration of Andrographis paniculata extract
- Phanit Songvut
- , Nanthanit Pholphana
- & Jutamaad Satayavivad
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| Open AccessHerb-anticancer drug interactions in real life based on VigiBase, the WHO global database
- Stéphanie Pochet
- , Anne-Sophie Lechon
- & Florence Souard
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| Open AccessA randomised study to assess the nicotine pharmacokinetics of an oral nicotine pouch and two nicotine replacement therapy products
- David Azzopardi
- , James Ebajemito
- & James Murphy
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| Open AccessIn vivo dose–response analysis to acetylcholine: pharmacodynamic assessment by polarized reflectance spectroscopy
- Joakim Henricson
- , Folke Sjöberg
- & Daniel Wilhelms
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Article
| Open Access89Zr-PET imaging to predict tumor uptake of 177Lu-NNV003 anti-CD37 radioimmunotherapy in mouse models of B cell lymphoma
- Danique Giesen
- , Marjolijn N. Lub-de Hooge
- & Martin Pool
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| Open AccessIn vivo imaging with two-photon microscopy to assess the tumor-selective binding of an anti-CD137 switch antibody
- Chisato Kaneko
- , Haruka Tsutsui
- & Masaru Ishii
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| Open AccessOptimization of supercritical-CO2 extraction and pharmacokinetics in SD rats of alkaloids form Sophora moorcroftiana seed
- Chunhui Hu
- , Xuehui Gan
- & Fabin Zhang
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| Open AccessCitrate pharmacokinetics in critically ill liver failure patients receiving CRRT
- Peerapat Thanapongsatorn
- , Weerachai Chaijamorn
- & Nattachai Srisawat
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| Open AccessBioinformatics approaches identified dasatinib and bortezomib inhibit the activity of MCM7 protein as a potential treatment against human cancer
- Abdus Samad
- , Md. Amdadul Huq
- & Md. Shahedur Rahman
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| Open AccessUrinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
- Kumiko Taira
- , Tomonori Kawakami
- & Makiko Komori
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| Open AccessExtract from Dioscorea bulbifera L. rhizomes aggravate pirarubicin-induced cardiotoxicity by inhibiting the expression of P-glycoprotein and multidrug resistance-associated protein 2 in the mouse liver
- Li-rui Sun
- , Qiu-shi Guo
- & Min Li
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| Open AccessPopulation pharmacokinetic model of cefazolin in total hip arthroplasty
- J. Lanoiselée
- , R. Chaux
- & E. Ollier
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| Open AccessAzithromycin concentrations during long-term regimen, a pilot study in patients with MALT lymphoma
- Raphael Scheibenpflug
- , Markus Obermüller
- & Heimo Lagler
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| Open AccessExcessive unbound cefazolin concentrations in critically ill patients receiving veno-arterial extracorporeal membrane oxygenation (vaECMO): an observational study
- Hendrik Booke
- , Otto R. Frey
- & Elisabeth H. Adam
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Article
| Open AccessAcetylation turns leucine into a drug by membrane transporter switching
- Grant C. Churchill
- , Michael Strupp
- & Antony Galione
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| Open AccessCannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations
- Lyndsey L. Anderson
- , Maia G. Etchart
- & Jonathon C. Arnold
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| Open AccessPharmacological and clinical evaluation of deferasirox formulations for treatment tailoring
- Andrea Piolatto
- , Paola Berchialla
- & Filomena Longo
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| Open AccessGenetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis
- Patrick Vizeli
- , Isabelle Straumann
- & Matthias E. Liechti
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| Open AccessA novel method for the storage and transport of biological samples of therapeutic proteins prior to the detection of analytes using ELISA
- Lei Wang
- , Lixiong Liu
- & Zeneng Cheng
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| Open AccessDevelopment and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases
- Muhammad F. Rasool
- , Shazia Ali
- & Faleh Alqahtani
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| Open AccessPharmacokinetics and metabolomics investigation of an orally modified formula of standardized Centella asiatica extract in healthy volunteers
- Phanit Songvut
- , Pajaree Chariyavilaskul
- & Rossarin Tansawat
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| Open AccessEnteric reabsorption processes and their impact on drug pharmacokinetics
- Manuel Ibarra
- , Iñaki F. Trocóniz
- & Pietro Fagiolino
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| Open AccessA versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses
- Pim de Haan
- , Milou J. C. Santbergen
- & Elisabeth Verpoorte
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| Open AccessSynthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody
- Takahiro Morito
- , Ryuichi Harada
- & Kazuhiko Yanai
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| Open AccessOral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
- Dong Liang
- , Jing Ma
- & Bo Wei
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| Open AccessEvaluation for pharmacokinetic exposure of cytotoxic anticancer drugs in elderly patients receiving (R-)CHOP therapy
- Junichi Nakagawa
- , Takenori Takahata
- & Takenori Niioka
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| Open AccessEarly impact of donor CYP3A5 genotype and Graft-to-Recipient Weight Ratio on tacrolimus pharmacokinetics in pediatric liver transplant patients
- Michele Pinon
- , Amedeo De Nicolò
- & Pier Luigi Calvo
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| Open AccessA randomised controlled single-centre open-label pharmacokinetic study to examine various approaches of nicotine delivery using electronic cigarettes
- James K. Ebajemito
- , Michael McEwan
- & Christopher J. Proctor
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| Open AccessPharmacokinetic–pharmacodynamic modelling of the hypoglycaemic effect of pulsatile administration of human insulin in rats
- Makoto Miyazaki
- , Mariko Hayata
- & Junya Nagai
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| Open AccessPreparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties
- Brice Martin
- , Johanne Seguin
- & Yohann Corvis
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| Open AccessA double-Flp-in method for stable overexpression of two genes
- Ole Jensen
- , Salim Ansari
- & Jürgen Brockmöller
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| Open AccessCombinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin
- Chih-hsuan Hsin
- , Marc S. Stoffel
- & Max Taubert
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| Open AccessThe concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics
- Justyna Schubert
- , Tanja Khosrawipour
- & Veria Khosrawipour
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| Open AccessSoluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy
- Lucia Scarabel
- , Marica Garziera
- & Silvano Geremia
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| Open AccessTime-resolved fluorescence microscopy with phasor analysis for visualizing multicomponent topical drug distribution within human skin
- Sinyoung Jeong
- , Daniel A. Greenfield
- & Conor L. Evans