Nucleosomes articles within Nature

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  • Article
    | Open Access

    Cryo-electron microscopy structures of human RAD51 in complex with the nucleosome show that RAD51 can adopt two conformations—rings and filaments—and reveal how RAD51 binds to the nucleosome through its N-terminal lobe domain.

    • Takuro Shioi
    • , Suguru Hatazawa
    •  & Hitoshi Kurumizaka

  • Article |

    Structures of the yeast replisome associated with the FACT complex and an evicted histone hexamer offer insights into the mechanism of replication-coupled histone recycling for maintaining epigenetic inheritance.

    • Ningning Li
    • , Yuan Gao
    •  & Yuanliang Zhai

  • Article
    | Open Access

    Cryo-EM structures and analysis provide insight into the mechanisms by which basic helix–loop–helix transcription factors access E-box DNA sequences that are embedded within nucleosomes, and cooperate with other transcription factors.

    • Alicia K. Michael
    • , Lisa Stoos
    •  & Nicolas H. Thomä

  • Article
    | Open Access

    Binding of the human pioneer transcription factor OCT4 to nucleosomes containing endogenous DNA sequences causes changes to the nucleosome structure and facilitates the cooperative assembly of multiple pioneer transcription factors, a property that can be affected by histone modifications.

    • Kalyan K. Sinha
    • , Silvija Bilokapic
    •  & Mario Halic

  • Article |

    A high-throughput, chromosome-wide analysis of DNA looping reveals its contribution to the organization of chromatin, and provides insight into how nucleosomes are deposited and organised de novo.

    • Aakash Basu
    • , Dmitriy G. Bobrovnikov
    •  & Taekjip Ha

  • Article |

    Cryo-electron microscopy structures of the DNA-binding domains of the pioneer transcription factor SOX2 and its close homologue SOX11 elucidate the role of these factors in initiating chromatin opening and nucleosome remodelling.

    • Svetlana O. Dodonova
    • , Fangjie Zhu
    •  & Patrick Cramer

  • Article |

    Structural studies on the yeast transcription coactivator complex SAGA (Spt–Ada–Gcn5–acetyltransferase) provide insights into the mechanism of initiation of regulated transcription by this multiprotein complex, which is conserved among eukaryotes.

    • Haibo Wang
    • , Christian Dienemann
    •  & Patrick Cramer

  • Article |

    Two cryo-electron-microscopy images of the histone chaperone FACT interacting with components of nucleosomes shed light on how FACT manipulates nucleosomes to promote transcription, DNA repair and DNA replication.

    • Yang Liu
    • , Keda Zhou
    •  & Karolin Luger

  • Article |

    Cryo-electron microscopy structures reveal that the DNA-repair factor UV-DDB exposes inaccessible nucleosome lesions for binding by inducing a translational shift in the nucleosome position.

    • Syota Matsumoto
    • , Simone Cavadini
    •  & Nicolas H. Thomä

  • Letter |

    Retroviruses such as HIV rely on the intasome, a tetramer of integrase protein bound to the viral DNA ends interacting with host chromatin, for integration into the host genome; the structure of the intasome as it interacts with a nucleosome is now solved, giving insight into the integration process.

    • Daniel P. Maskell
    • , Ludovic Renault
    •  & Peter Cherepanov

  • Letter |

    The authors identify a specific histone variant as a memory-suppressor that is initially reduced in expression within the hippocampus during memory formation; as a memory is consolidated to the cortex, reduced histone association with specific plasticity genes is observed, promoting stabilization of the memory.

    • Iva B. Zovkic
    • , Brynna S. Paulukaitis
    •  & J. David Sweatt

  • Letter |

    The transcription start sites used during the maternal to zygotic transition in zebrafish are mapped, revealing that the transition is characterized by a switch between two different sequence signs to guide transcription initiation, which often co-exist in core promoters.

    • Vanja Haberle
    • , Nan Li
    •  & Boris Lenhard

  • Letter |

    The crystal structure of the FACT histone chaperone domain Spt16M in complex with the H2A–H2B heterodimer is solved; Spt16M makes several interactions with histones and seems to block the interaction of H2B with DNA, which could explain how FACT destabilizes nucleosomes to promote transcription.

    • Maria Hondele
    • , Tobias Stuwe
    •  & Andreas G. Ladurner

  • Letter |

    Two separate regulatory regions on the Drosophila chromatin remodeller ISWI are defined, AutoN and NegC, which negatively regulate ATP hydrolysis and the coupling of ATP hydrolysis to productive DNA translocation, respectively; epitopes on nucleosomes activate ISWI by inhibiting these negative regulatory domains, ensuring that remodelling occurs only in the appropriate chromatin context.

    • Cedric R. Clapier
    •  & Bradley R. Cairns

  • News & Views |

    Cells replicate half of their genome as short fragments that are put together later on. The way in which this process is linked to the formation of DNA–protein complexes called nucleosomes is now becoming clearer. See Article p.434

    • Alysia Vandenberg
    •  & Geneviève Almouzni

  • Article |

    The small GTPase Ran regulates nuclear transport and cell division by creating a gradient of RanGTP around chromosomes. The RCC1 protein recruits Ran to nucleosomes and activates Ran's nucleotide exchange activity. Here, the crystal structure of the complex between RCC1 and the nucleosome core particle is revealed. It provides an atomic view of how a chromatin protein interacts with the histone and DNA components of the nucleosome.

    • Ravindra D. Makde
    • , Joseph R. England
    •  & Song Tan

  • Letter |

    Nucleosomes are composed of around 147 bases of DNA wrapped around an octamer of histone proteins. Here, a genome-wide analysis of nucleosome positioning in Arabidopsis thaliana has been combined with profiles of DNA methylation at single base resolution, revealing 10-base periodicities in the DNA methylation status of nucleosome-bound DNA. The results indicate that nucleosome positioning influences the pattern of DNA methylation throughout the genome.

    • Ramakrishna K. Chodavarapu
    • , Suhua Feng
    •  & Matteo Pellegrini

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