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News & Views |
Yielding substrates for neurons
Soft culture substrates improve the yield of functional motor neurons derived from human pluripotent stem cells.
- Emily Rhodes Lowry
- & Christopher E. Henderson
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Article |
A transparent organic transistor structure for bidirectional stimulation and recording of primary neurons
A transparent organic field-effect transistor allows the stimulation and recording of the bioelectrical activity of primary neural cells. The cells grow, differentiate and function on the device, which then provides the electrical stimulation, and enables the recording of extracellular current and optical imaging of the modulation of neuronal membrane potential.
- Valentina Benfenati
- , Stefano Toffanin
- & Michele Muccini
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Article |
Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces
Implantable neural microelectrodes are critical to neuroscience research and emerging clinical applications including brain-controlled prostheses. A composite electrode consisting of a carbon fibre core, an insulating polymer coating and a polythiophene-based recording pad has now been developed that shows reduced chronic reactive tissue response in rats compared with existing architectures, owing to its smaller size and improved mechanical compliance with brain tissue.
- Takashi D. Yoshida Kozai
- , Nicholas B. Langhals
- & Daryl R. Kipke
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Letter |
Short-term plasticity and long-term potentiation mimicked in single inorganic synapses
The electronic properties of inorganic devices such as memristors can be used to simulate neurological behaviour. In particular, ionic and electronic effects in a silver sulphide device are now shown to mimic short- and long-term synaptic functions.
- Takeo Ohno
- , Tsuyoshi Hasegawa
- & Masakazu Aono
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Editorial |
A matter of choice
The United Kingdom's tough budget for science may force researchers to pick winners and losers. But can it work?
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