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Oestrogen engages brain MC4R signalling to drive physical activity in female mice
A subset of oestrogen-sensitive neurons integrate melanocortin and oestrogen signalling to rebalance energy allocation in female mice leading to reduced sedentary behaviour and decreasing obesity in oestrogen-depleted female mice
- William C. Krause
- , Ruben Rodriguez
- & Holly A. Ingraham
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A metabolic function of the hippocampal sharp wave-ripple
Sharp wave-ripples from the hippocampus are shown to modulate peripheral glucose homeostasis in rats, offering insights into the mechanism that links sleep disruption and blood glucose regulation in type 2 diabetes.
- David Tingley
- , Kathryn McClain
- & György Buzsáki
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REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity
REV-ERB in GABAergic neurons orchestrates the rhythmic sensitivity of hepatic glucose production to insulin-mediated suppression that peaks at wakening, with implications in the extended dawn phenomenon.
- Guolian Ding
- , Xin Li
- & Zheng Sun
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Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons
Mice possess neurons in the preoptic area of the hypothalamus that are sensitive to violet light; these deep brain neurons sense light via OPN5 and regulate adaptive thermogenesis in brown fat.
- Kevin X. Zhang
- , Shane D’Souza
- & Richard A. Lang
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Research Highlights |
Hormone linked to depression
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Self-formation of functional adenohypophysis in three-dimensional culture
Mouse embryonic stem cells are induced to form functional anterior pituitary tissue in three-dimensional culture.
- Hidetaka Suga
- , Taisuke Kadoshima
- & Yoshiki Sasai
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Research Highlights |
Hungry cells eat from within
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Article |
Functional identification of an aggression locus in the mouse hypothalamus
Certain regions of the hypothalamus are important in aggression, but until recently, it has been difficult to specifically stimulate specific cell types within a mixed population of cells. Here, optogenetics is used to solve this specificity problem, finding that optogenetic stimulation of a subdivision within the ventromedial hypothalamus can elicit inappropriate attack behaviours in mice, but electrical stimulation does not produce the same result. Additional analysis of genetic and electrophysiological activity revealed overlapping neuronal subpopulations involved in fighting and mating, with potential competition between these behaviours, as neurons activated during aggression are inhibited during mating.
- Dayu Lin
- , Maureen P. Boyle
- & David J. Anderson
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News |
Protein hormone boosts memory
Research in rats indicates new target for memory enhancement.
- Tiffany O’Callaghan