Featured
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Article |
Programmable icosahedral shell system for virus trapping
Programmable triangular DNA blocks self-assemble into distinct icosahedral shells with specific geometry and apertures that can encapsulate viruses and decrease viral infection.
- Christian Sigl
- , Elena M. Willner
- & Hendrik Dietz
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News & Views |
Life and death agendas of actin filaments
Cancer cells have now been shown to lack rigidity-sensing due to alteration in cytoskeletal sensor proteins, but can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.
- Edna C. Hardeman
- & Peter W. Gunning
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News & Views |
Building nanobridges for cell adhesion
Nanofibre mimetic substrates reveal the presence of integrin nanoclusters bridged by unliganded receptors during early cell–matrix adhesion.
- E. Ada Cavalcanti-Adam
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Letter |
Cellular nanoscale stiffness patterns governed by intracellular forces
High-spatial-resolution mechanical imaging reveals that intracellular forces generate cellular nanoscale stiffness patterns.
- Nicola Mandriota
- , Claudia Friedsam
- & Ozgur Sahin
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News & Views |
Instant integrin mechanosensing
Single-cell force spectroscopy reveals rapid, biphasic integrin activation and reinforcement of cell–matrix bonds during the initial steps of fibroblast adhesion.
- Ning Wang
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Article |
Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second
Integrins play an important role in the adhesion of cells to their matrix. Here, the authors investigate how fibroblasts respond to mechanical loads, at the onset of cell adhesion to fibronectin, in distinct phases that are modulated by integrins.
- Nico Strohmeyer
- , Mitasha Bharadwaj
- & Daniel J. Müller
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Article |
The processing and heterostructuring of silk with light
Femtosecond laser pulses can induce local bulging or plasma ablation of silk with limited structural damage, thus offering a technique for cutting, patterning, bending and welding of silk with various other materials.
- Mehra S. Sidhu
- , Bhupesh Kumar
- & Kamal P. Singh