Muscle stem cells articles within Nature Communications

Featured

• Article | 14 August 2014

  miR-195/497 induce postnatal quiescence of skeletal muscle stem cells

  Skeletal muscle stem cells are in a state of cell cycle arrest in adult skeletal muscles and are stimulated to proliferate and differentiate in response to injury or pathology. Here the authors identify two microRNAs, miR-195 and miR-497, which induce cell cycle arrest in the stem cells and suppress myogenesis.

  • Takahiko Sato
  • , Takuya Yamamoto
  •  & Atsuko Sehara-Fujisawa

• Article | 07 June 2013

  Collagen VI regulates satellite cell self-renewal and muscle regeneration

  Satellite cells have important roles in homeostasis and regeneration of skeletal muscles. Urciuolo et al. show that the extracellular matrix protein collagen VI is required for preserving satellite cell self-renewal and muscle regeneration in vitro and in vivoby modulating muscle mechanical properties.

  • Anna Urciuolo
  • , Marco Quarta
  •  & Paolo Bonaldo

• Article | 12 June 2012

  Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity

  Stem cells hold great potential for therapeutic use but their supply is limited. Latilet al.isolate muscle stem cells from human and mouse cadavers after 17 and 14 days, respectively, and show that when transplanted into mice the cells can regenerate tissues.

  • Mathilde Latil
  • , Pierre Rocheteau
  •  & Fabrice Chrétien

• Article
  03 January 2012 | Open Access

  Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

  The function of adult stem cells is diminished with age but the role this dysfunction plays in the aging process is unknown. Here, the injection of muscle-derived stem/progenitor cells from young mice rescues symptoms in progeroid mice and is shown to regenerate tissues independent of engraftment.

  • Mitra Lavasani
  • , Andria R. Robinson
  •  & Johnny Huard