Featured
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Article |
Injectable tissue integrating networks from recombinant polypeptides with tunable order
A protein-based material with temperature-modulated mechanical properties and function is achieved by the rational incorporation of structural ordering and disordering elements into its polypeptide sequence.
- Stefan Roberts
- , Tyler S. Harmon
- & Ashutosh Chilkoti
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Feature |
Adoptive T cell cancer therapy
Tumour heterogeneity and off-target toxicity are current challenges of cancer immunotherapy. Karine Dzhandzhugazyan, Per Guldberg and Alexei Kirkin discuss how epigenetic induction of tumour antigens in antigen-presenting cells may form the basis for multi-target therapies.
- Karine N. Dzhandzhugazyan
- , Per Guldberg
- & Alexei F. Kirkin
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News & Views |
Into the groove
Adult cells can be routinely reprogrammed into pluripotent stem cells by chemical and genetic means, such as the expression of a cocktail of exogenous transcription factors. It is now shown that growing cells on substrates with aligned features such as microgrooves can enhance this process.
- Yan Xu
- , Longqi Liu
- & Miguel A. Esteban
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Article |
Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing
Small interfering ribonucleic acid (siRNA) is used to silence genes and treat conditions such as human immunodeficiency virus. Safe and efficient delivery, however, is proving problematic. A new class of biologically active siRNA polyelectrolyte complexes based on chemically self-crosslinked siRNA is presented, which shows greatly enhanced gene-silencing efficiencies in vitro and in vivo without significantly eliciting an immune response.
- Hyejung Mok
- , Soo Hyeon Lee
- & Tae Gwan Park
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- Cell division
- Chromatin
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- CRISPR-Cas systems
- DNA damage and repair
- DNA metabolism
- DNA recombination
- DNA replication
- Epigenetics
- Non-coding RNAs
- Nuclear organization
- Post-translational modifications
- Protein folding
- Proteolysis
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- Riboswitches
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- RNA metabolism
- RNAi
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