Featured
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Editorial
| Open AccessMitochondrial dynamics: updates and perspectives
Mitochondria, the powerhouse and the vital signaling hub of the cell, participate in a variety of biological processes, such as apoptosis, redox responses, cell senescence, autophagy, and iron homeostasis. Mitochondria form a mostly tubular network, made up of an outer and a cristeae-forming inner membrane. The network undergoes dynamic fusion and fission that change its morphological structure according to the functional needs. Approximately 1500 mitochondrial proteins encoded by nuclear genome plus over 10 proteins encoded by mitochondrial DNA are folded and assembled in the mitochondria under a high-fidelity control system. These proteins are involved in oxidative phosphorylation, metabolism, network and cristae dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance. This Collection gathers original research that advances our understanding of the monitoring techniques and pathophysiological significance of mitochondrial dynamics in health and disease.
- Kezhong Zhang
- & Ježek Petr
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Article
| Open AccessPolyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions
- Nina Kunová
- , Gabriela Ondrovičová
- & Vladimír Pevala
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Article
| Open AccessMitochondrial Ca2+ signaling is a hallmark of specific adipose tissue-cancer crosstalk
- Agnese De Mario
- , Elisabetta Trevellin
- & Cristina Mammucari
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Article
| Open AccessBalbiani body of basal insects is potentially involved in multiplication and selective elimination of mitochondria
- Malgorzata Sekula
- , Waclaw Tworzydlo
- & Szczepan M. Bilinski
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Article
| Open AccessBioenergetic impairment in Gulf War illness assessed via 31P-MRS
- Beatrice Alexandra Golomb
- , Jun Hee Han
- & Gavin Hamilton
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Article
| Open AccessMicrocirculation-driven mitochondrion dysfunction during the progression of experimental sepsis
- Roland Fejes
- , Attila Rutai
- & Szabolcs Péter Tallósy
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Article
| Open AccessMiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4
- Jianbing Zhu
- , Qian Wang
- & Junbo Ge
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Article
| Open AccessVitamin K2 protects mice against non-alcoholic fatty liver disease induced by high-fat diet
- Peizuo Zhao
- , Weidong Yang
- & Shuzhuang Li
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Article
| Open AccessMitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy
- Doménica Tarallo
- , Jennyfer Martínez
- & Celia Quijano
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Article
| Open AccessThe nascent polypeptide-associated complex subunit Egd1 is required for efficient selective mitochondrial degradation in budding yeast
- Yuan Tian
- & Koji Okamoto
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Article
| Open AccessArresting calcium-regulated sperm metabolic dynamics enables prolonged fertility in poultry liquid semen storage
- Pangda Sopha Sushadi
- , Maiko Kuwabara
- & Atsushi Asano
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Article
| Open AccessCharacteristics and time points to inhibit ferroptosis in human osteoarthritis
- Yangyang Xu
- , Zhenyu Yang
- & Qingqi Meng
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Article
| Open AccessA Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise
- Kirsten T. Nijholt
- , Pablo I. Sánchez-Aguilera
- & B. Daan Westenbrink
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Article
| Open AccessPan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types
- Ilya N. Boykov
- , McLane M. Montgomery
- & Kelsey H. Fisher-Wellman
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Article
| Open AccessMRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response
- Danhong Lin
- , Jingwen Yu
- & Huibiao Quan
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Article
| Open AccessCharacterization of signal and transit peptides based on motif composition and taxon-specific patterns
- Katarzyna Sidorczuk
- , Paweł Mackiewicz
- & Przemysław Gagat
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Article
| Open AccessRemdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation
- Nicole DeFoor
- , Swagatika Paul
- & Alicia M. Pickrell
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Article
| Open AccessEnhanced presynaptic mitochondrial energy production is required for memory formation
- Erica L. Underwood
- , John B. Redell
- & Pramod K. Dash
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Article
| Open AccessEvidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6
- James M. Gruschus
- , Daniel L. Morris
- & Nico Tjandra
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Article
| Open AccessCharacterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy
- Hiroko Ueda
- , Quynh Thuy Huong Tran
- & Hiroyasu Tsukaguchi
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Article
| Open AccessLongitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency
- K. L. Stauch
- , S. Totusek
- & H. S. Fox
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Article
| Open AccessPlatelets from patients with myeloproliferative neoplasms have increased numbers of mitochondria that are hypersensitive to depolarization by thrombin
- David M. Ross
- , Hai Po Helena Liang
- & Vivien M. Chen
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Article
| Open AccessReducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice
- Kim Reid
- , Eileen G. Daniels
- & Keir J. Menzies
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Article
| Open AccessPCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans
- Vera H. W. de Wit-Verheggen
- , Vera B. Schrauwen-Hinderling
- & Tineke van de Weijer
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Article
| Open AccessReduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis
- R. Undamatla
- , O. G. Fagunloye
- & M. J. Jurczak
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Article
| Open AccessMitochondrial citrate metabolism and efflux regulate BeWo differentiation
- Renee M. Mahr
- , Snehalata Jena
- & Sarah A. Wernimont
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Article
| Open AccessPossible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells
- Vojtěch Pavluch
- , Tomáš Špaček
- & Petr Ježek
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Article
| Open AccessRescuing cellular function in Fuchs endothelial corneal dystrophy by healthy exogenous mitochondrial internalization
- Sébastien Méthot
- , Stéphanie Proulx
- & Patrick J. Rochette
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Article
| Open AccessThe injections of mitochondrial fusion promoter M1 during proestrus disrupt the progesterone secretion and the estrous cycle in the mouse
- Yovita Permata Budi
- , Meng-Chieh Hsu
- & Yi-Fan Jiang
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Article
| Open AccessInner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
- Kibrom M. Alula
- , Yaritza Delgado-Deida
- & Arianne L. Theiss
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Article
| Open AccessSex and menopause impact 31P-Magnetic Resonance Spectroscopy brain mitochondrial function in association with 11C-PiB PET amyloid-beta load
- Steven Jett
- , Jonathan P. Dyke
- & Lisa Mosconi
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Article
| Open AccessAn increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration
- Agalya Periasamy
- , Naomi Mitchell
- & Jacqueline M. Gulbis
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Article
| Open AccessSuperior cardiometabolic and cellular adaptive responses to multiple versus single daily sessions of high-intensity interval training in Wistar rats
- Bruno Ferreira Mendes
- , Liliane Vanessa Costa-Pereira
- & Marco Fabrício Dias-Peixoto
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Article
| Open AccessThe mitochondrial Ca2+ uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca2+ oscillations
- Akshar Patel
- , Matthew Simkulet
- & B. Rita Alevriadou
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Article
| Open AccessRhodiola pre-conditioning reduces exhaustive exercise-induced myocardial injury of insulin resistant mice
- Baiyang You
- , Jing Cheng
- & Suixin Liu
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Article
| Open AccessDelivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death
- Erina Toki
- , Shotaro Goto
- & Jiro Takata
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Article
| Open AccessMesenchymal stem cell bioenergetics and apoptosis are associated with risk for bronchopulmonary dysplasia in extremely low birth weight infants
- Snehashis Hazra
- , Rui Li
- & Jegen Kandasamy
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Article
| Open AccessUniversal dynamics of mitochondrial networks: a finite-size scaling analysis
- Nahuel Zamponi
- , Emiliano Zamponi
- & Dante R. Chialvo
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Article
| Open AccessDichloroacetate as a metabolic modulator of heart mitochondrial proteome under conditions of reduced oxygen utilization
- Natalia Andelova
- , Iveta Waczulikova
- & Miroslav Ferko
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Article
| Open AccessMitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos
- Marta Czernik
- , Dawid Winiarczyk
- & Pasqualino Loi
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Article
| Open AccessThe relationships between growth rate and mitochondrial metabolism varies over time
- Jean-Baptiste Quéméneur
- , Morgane Danion
- & Karine Salin
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Article
| Open AccessMitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines
- Maria Carmo Greier
- , Annette Runge
- & Herbert Riechelmann
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Article
| Open AccessIn-resin CLEM of Epon-embedded cells using proximity labeling
- Takahito Sanada
- , Junji Yamaguchi
- & Yasuo Uchiyama
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Article
| Open AccessEvidence for mitochondrial Lonp1 expression in the nucleus
- Lara Gibellini
- , Rebecca Borella
- & Marcello Pinti
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Article
| Open AccessReconstruction of functional human epidermis equivalent containing 5%IPS-derived keratinocytes treated with mitochondrial stimulating plant extracts
- Marielle Moreau
- , Christophe Capallere
- & Anne-Laure Bulteau
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Article
| Open AccessImpact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells
- Luke Goudie
- , Nicole L. Mancini
- & Jane Shearer
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| Open AccessThe SNPs of mitochondrial DNA displacement loop region and mitochondrial DNA copy number associated with risk of polymyositis and dermatomyositis
- Yufei Zhao
- , Chenxing Peng
- & Zhanjun Guo
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Article
| Open AccessTransplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect
- Daisuke Sasaki
- , Jiro Abe
- & Yuma Yamada
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Article
| Open AccessMetabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension
- V. F. E. D. Smolders
- , C. Rodríguez
- & O. Tura-Ceide