Featured
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| Open AccessA rat-based preclinical platform facilitating transcatheter hepatic arterial infusion in immunodeficient rats with liver xenografts of patient-derived pancreatic ductal adenocarcinoma
- Masanori Ozaki
- , Ken Kageyama
- & Yukio Miki
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Article
| Open AccessNew treatment alternatives for primary and metastatic colorectal cancer by an integrated transcriptome and network analyses
- Caner Karaca
- , Ezgi Demir Karaman
- & Yasemin Basbinar
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Article
| Open AccessPrognosis significance and potential association between ALDOA and AKT expression in colorectal cancer
- Menglin Xu
- , Shihang Xi
- & Zhengwu Cheng
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Article
| Open AccessCreation of a machine learning-based prognostic prediction model for various subtypes of laryngeal cancer
- Wei Wang
- , Wenhui Wang
- & Chengfu Cai
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| Open AccessComparison of surgical outcomes for hip fracture between older patients with and without cancer: a propensity score matching analysis
- Chul-Ho Kim
- , Kyu-pyo Kim
- & Ji Wan Kim
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| Open AccessOpportunistic screening with multiphase contrast-enhanced dual-layer spectral CT for osteoblastic lesions in prostate cancer compared with bone scintigraphy
- Ming-Cheng Liu
- , Chi-Chang Ho
- & Yi-Jui Liu
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Article
| Open AccessCysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer
- Liangming Zhang
- , Xiongfeng Chen
- & Yi Huang
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Article
| Open Accessα-lipoic acid modulates prostate cancer cell growth and bone cell differentiation
- K. M. Abdullah
- , Gunjan Sharma
- & Jawed A. Siddiqui
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Article
| Open AccessSurvival outcome and prognostic factors for early-onset and late-onset metastatic colorectal cancer: a population based study from SEER database
- Bingyi Ren
- , Yichen Yang
- & Kang Liu
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Article
| Open AccessA dynamic visualization clinical tool constructed and validated based on the SEER database for screening the optimal surgical candidates for bone metastasis in primary kidney cancer
- Liming Jiang
- , Yuexin Tong
- & Dongxu Zhao
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Article
| Open AccessLong noncoding RNA SNHG1 promotes breast cancer progression by regulating the miR-641/RRS1 axis
- Lin Deng
- , Jun Wang
- & Lin Hou
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Article
| Open AccessPSGL-1 decorated with sialyl Lewisa/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement
- Michael O’Dwyer
- , Lucy Kirkham-McCarthy
- & Alessandro Natoni
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Article
| Open AccessCooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodia
- Yutaka Yasuta
- , Ryuya Kaminaka
- & Satoru Yokoyama
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| Open Access1H-NMR metabolomics analysis identifies hypoxanthine as a novel metastasis-associated metabolite in breast cancer
- Sarra B. Shakartalla
- , Naglaa S. Ashmawy
- & Sameh S. M. Soliman
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Article
| Open AccessSIRT6 promotes metastasis and relapse in HER2-positive breast cancer
- Cristina Andreani
- , Caterina Bartolacci
- & Augusto Amici
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Article
| Open AccessSOCS2 inhibits hepatoblastoma metastasis via downregulation of the JAK2/STAT5 signal pathway
- Yong Lv
- , Xiaolong Xie
- & Bo Xiang
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Editorial
| Open AccessLiquid biopsy: from concept to clinical application
The diagnosis and treatment of cancer presents a physical and mental burden to the patient, often involving diagnostic biopsies and surgeries or chemotherapeutic approaches with severe side-effects. Advances which enable early detection of cancer and close monitoring of the disease course without invasive procedures, and which can underpin a tailored approach to treatment, can therefore make a big difference to the quality of life of patients. Liquid biopsies can be used to access tumor cells and tumor DNA circulating in the blood. Monitoring these species can provide a minimally invasive and repeatable means to detect cancer, or gain information about its response to treatment.
- Catherine Alix-Panabières
- , Dario Marchetti
- & Julie E. Lang
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| Open AccessA deep learning model predicts the presence of diverse cancer types using circulating tumor cells
- Somayah Albaradei
- , Nofe Alganmi
- & Xin Gao
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Article
| Open AccessBrain metastasis, EGFR mutation subtype and generation of EGFR-TKI jointly influence the treatment outcome of patient with EGFR-mutant NSCLC
- Jia-Shiuan Ju
- , Allen Chung-Cheng Huang
- & Cheng-Ta Yang
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Article
| Open AccessMultifractal analysis of cellular ATR-FTIR spectrum as a method for identifying and quantifying cancer cell metastatic levels
- Ayan Barbora
- , Sirish Karri
- & Refael Minnes
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Article
| Open AccessEvaluation of cell surface vimentin positive circulating tumor cells as a prognostic biomarker for stage III/IV colorectal cancer
- Jiazi Yu
- , Mian Yang
- & Yuepeng Cao
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Article
| Open AccessSinonasal mucosal melanoma treatment response assessment to immune checkpoint inhibitors using hybrid positron emission tomography imaging
- Alexander Maurer
- , Nathalie A. Gstrein
- & Christian M. Meerwein
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Article
| Open AccessIdentification and validation of novel prognostic signatures based on m5C methylation patterns and tumor EMT profiles in head and neck squamous cell carcinoma
- Guanghao Zhu
- , Wei Wang
- & Hongliang Zheng
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Article
| Open AccessPrimary breast tumor induced extracellular matrix remodeling in premetastatic lungs
- Ruoqing Cai
- , Caitlin M. Tressler
- & Kristine Glunde
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Article
| Open AccessThe importance of planning CT-based imaging features for machine learning-based prediction of pain response
- Óscar Llorián-Salvador
- , Joachim Akhgar
- & Jan C. Peeken
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Article
| Open AccessGame-theoretical description of the go-or-grow dichotomy in tumor development for various settings and parameter constellations
- Shalu Dwivedi
- , Christina Glock
- & Stefan Schuster
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Article
| Open AccessEpigenomic analysis reveals a unique DNA methylation program of metastasis-competent circulating tumor cells in colorectal cancer
- Aida Bao-Caamano
- , Nicolás Costa-Fraga
- & Angel Díaz-Lagares
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Article
| Open AccessOrosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization
- Lei Yue
- , Xiaozhang Xu
- & Xiaofeng Qian
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Article
| Open AccessEffect of whole-brain radiotherapy with platinum-based chemotherapy in non-small cell lung cancer patients with multiple metastases including brain metastases
- Woo Kyung Ryu
- , Hyung Keun Cha
- & Jun Hyeok Lim
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Article
| Open Access99mTc-macroaggregated albumin SPECT/CT predictive dosimetry and dose-response relationship in uveal melanoma liver metastases treated with first-line selective internal radiation therapy
- Flavian Tabotta
- , Silvano Gnesin
- & Rafael Duran
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Article
| Open AccessA 3-month survival model after Gamma Knife surgery in patients with brain metastasis from lung cancer with Karnofsky performance status ≤ 70
- Hangeul Park
- , Hyun-Tai Chung
- & Eun Jung Lee
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Article
| Open AccessEncapsulation and adhesion of nanoparticles as a potential biomarker for TNBC cells metastatic propensity
- Yulia Merkher
- , Elizaveta Kontareva
- & Sergey Leonov
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Article
| Open AccessHistone deacetylase inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1
- Dongmei Wang
- , Yixiao Yang
- & Liming Tang
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Article
| Open AccessMR imaging features to predict the type of bone metastasis in prostate cancer
- Hiroaki Koyama
- , Ryo Kurokawa
- & Osamu Abe
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Article
| Open AccessLiquid tumor microenvironment enhances WNT signaling pathway of peritoneal metastasis of gastric cancer
- Huawei Xu
- , Zhibin Hao
- & Xianbao Zhan
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Article
| Open AccessCYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathway
- Wenming Jia
- , Shuai Chen
- & Dapeng Lei
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Article
| Open AccessTPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma
- Xiang Li
- & Ruochuan Cheng
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Article
| Open AccessMTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways
- Zhuoying Lin
- , Yu Lei
- & Huaping Xie
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Article
| Open AccessBone scan index (BSI) scoring by using bone scintigraphy and circulating tumor cells (CTCs): predictive factors for enzalutamide effectiveness in patients with castration-resistant prostate cancer and bone metastases
- Hisashi Hirano
- , Masayoshi Nagata
- & Shigeo Horie
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Article
| Open AccessDiagnostic value of two-time point [68Ga]Ga-PSMA-11 PET/CT in the primary staging of untreated prostate cancer
- Friedrich Weitzer
- , Birgit Pernthaler
- & Reingard Maria Aigner
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Article
| Open AccessEndogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice
- Mostafa A. Aboouf
- , Julia Armbruster
- & Thomas A. Gorr
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Article
| Open AccessRNU12 inhibits gastric cancer progression via sponging miR-575 and targeting BLID
- Shaoli Wang
- , Changyan Zou
- & Xiandong Lin
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Article
| Open AccessMeasuring antigen expression of cancer cell lines and circulating tumour cells
- Anouk Mentink
- , Khrystany T. Isebia
- & Michiel Stevens
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Article
| Open AccessSuppression of CEBPδ recovers exhaustion in anti-metastatic immune cells
- Chenxue Yin
- , Masayoshi Kato
- & Sachie Hiratsuka
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Article
| Open AccessE-liquid alters oral epithelial cell function to promote epithelial to mesenchymal transition and invasiveness in preclinical oral squamous cell carcinoma
- Jefferson Muniz de Lima
- , Carolina Carneiro Soares Macedo
- & Sabrina Daniela da Silva
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Article
| Open AccessRegorafenib is suitable for advanced colorectal cancer patients who have previously received trifluridine/tipiracil plus bevacizumab
- Toshihiko Matsumoto
- , Tatsuki Ikoma
- & Hisateru Yasui
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| Open AccessADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer
- Nanako Hata
- , Kunitoshi Shigeyasu
- & Toshiyoshi Fujiwara
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Article
| Open AccessPatient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastases
- Theresa Kraft
- , Konrad Grützmann
- & Michael Seifert
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| Open AccessOverexpression of the NEK9–EG5 axis is a novel metastatic marker in pathologic stage T3 colon cancer
- Meejeong Kim
- , Hui Jeong Jeong
- & Jene Choi