Featured
-
-
Article
| Open Access
Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2
The inner ear is highly organized, with distinct domains being located across the Line of Polarity Reversal (LPR). Here they show that Emx2 establishes the LPR and bidirectional selectivity of otolith organs, and that loss of the LPR in mice affects swimming and balance.
- Young Rae Ji
- , Yosuke Tona
- & Doris K. Wu
-
Article
| Open Access
Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues
Although Hippo signaling restricts regeneration in many mammalian organs, the pharmaceutical tools available to modulate the pathway have been limited. Here, the authors report a small molecule that may inhibit a key element in the Hippo cascade and may activate regenerative responses in several mammalian tissues.
- Nathaniel Kastan
- , Ksenia Gnedeva
- & A. J. Hudspeth
-
Article
| Open Access
AAV2.7m8 is a powerful viral vector for inner ear gene therapy
Adeno-associated virus is used in gene therapy in mouse models of hearing loss. Here the authors compare vectors and find AAV2.7m8 can infect cells in the inner ear with high efficiency.
- Kevin Isgrig
- , Devin S. McDougald
- & Wade W. Chien
-
Article
| Open Access
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.
- Michael R. Bowl
- , Michelle M. Simon
- & Steve D. M. Brown
-
Article
| Open Access
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
Sensory hair cells from the mammalian inner ear do not regenerate. Here, the authors induce direct hair cell formation from mouse embryonic stem cells using a three-dimensional culture system and observe differentiation of Type I and Type II vestibular hair cells and establishment of synapses with neurons.
- Xiao-Ping Liu
- , Karl R. Koehler
- & Jeffrey R. Holt
-
Article
| Open Access
Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear
Heterogeneous sensory epithelia of the inner ear are difficult to study owing to the few cells that can be isolated. Here the authors provide insight into the developmental processes underlying the formation of these cells by single-cell RNA-Seq.
- Joseph C. Burns
- , Michael C. Kelly
- & Matthew W. Kelley
-
Article |
A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear
The auditory systems of animals that perceive sounds in air are organized so that mechanosensory hair cells located at different positions respond to specific frequencies. Here, Mann et al. find that a gradient of Bmp7 controls the determination of frequency-specific hair cell characteristics in the chick auditory system.
- Zoë F. Mann
- , Benjamin R. Thiede
- & Matthew W. Kelley
TRPA1 activation in non-sensory supporting cells contributes to regulation of cochlear sensitivity after acoustic trauma