Glycobiology articles from across Nature Portfolio

Exoglycosidases isolated from the mucolytic gut bacteria Akkermansia muciniphila bring enzymatic conversion of A and B blood group erythrocytes to blood group O a step closer.

Poly-β-(1–6)-N-acetylglucosamine (PNAG) is an important vaccine target, but the impact of the number and position of free amine vs N-acetylation on its antigenicity is not well understood. Here, the authors report a divergent strategy to synthesize a comprehensive library of PNAG pentasaccharides, enabling the identification of enhanced epitopes for vaccines against Staphylococcus aureus including drug resistant strains.

Pancreatic cancer-associated fibroblast enhance the expression of sialic acidcontaining glycans, which interact with Siglec7, -9, -10, -15 receptors on myeloid cells, and drive the differentiation to immunosuppressive macrophages.

Binding modes of antigenically drifted hemagglutinins of human influenza A viruses have been determined by NMR using synthetic N-glycans having ¹³C-labeled monosaccharides to pinpoint which monosaccharides of extended LacNAc chains engage with the HAs.

Exoglycosidases isolated from the mucolytic gut bacteria Akkermansia muciniphila bring enzymatic conversion of A and B blood group erythrocytes to blood group O a step closer.

Analyzing glycans is challenging because of their structural diversity and complexity and the lack of analytical techniques capable of resolving pools of similar glycan structures. A new method now enables imaging of single glycans, providing direct observation of individual glycans and glycoconjugates.

A recently discovered RNA species on the cell surface is studied by proximity ligation.