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Article
| Open AccessSignatures of mutation and selection in the cancer genome
Homozygous gene deletions in cancer cells occur over recessive cancer genes (where they can confer selective growth advantage) or over genes at fragile sites of the genome (where they are thought to reflect increased DNA breakage). Here, a large number of homozygous deletions in a collection of cancer cell lines are identified and analysed to derive structural signatures for the two different types of deletion. More deletions are found in inherently fragile regions, and fewer overlying recessive genes.
- Graham R. Bignell
- , Chris D. Greenman
- & Michael R. Stratton
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Article |
The landscape of somatic copy-number alteration across human cancers
One way of discovering genes with key roles in cancer development is to identify genomic regions that are frequently altered in human cancers. Here, high-resolution analyses of somatic copy-number alterations (SCNAs) in numerous cancer specimens provide an overview of regions of focal SCNA that are altered at significant frequency across several cancer types. An oncogenic function is also found for the anti-apoptosis genes MCL1 and BCL2L1, which reside in amplified genome regions in many cancers.
- Rameen Beroukhim
- , Craig H. Mermel
- & Matthew Meyerson
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Letter
| Open AccessComplete Khoisan and Bantu genomes from southern Africa
Until now, fully sequenced human genomes of the indigenous hunter-gatherer peoples of southern Africa have been limited to recently diverged populations. The complete genome sequences of an indigenous hunter-gatherer from the Kalahari Desert and of a Bantu from southern Africa are now presented. The extent of whole-genome and exome diversity is characterized; the observed genomic differences may help to pinpoint genetic adaptations to an agricultural lifestyle.
- Stephan C. Schuster
- , Webb Miller
- & Vanessa M. Hayes
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Research Highlights |
Genetics: Two strikes
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News |
Africa yields two full human genomes
Sequences show rich diversity among the population.
- Heidi Ledford
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News & Views |
A chromatin thermostat
When environmental temperatures rise, plants seek help from their core molecular mechanisms to adapt. The chromatin protein H2A.Z, which regulates gene expression, is one such rescue molecule.
- Roger B. Deal
- & Steven Henikoff
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News & Views |
Random expression goes binary
The production of intestinal cells in a worm embryo is regulated by a network of transcription factors. Studies of these networks in mutant worms provide evidence for stochastic effects in gene expression.
- Adrian Streit
- & Ralf J. Sommer
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News |
Genomics firms turn to other markets
Next generation of machines could answer different research questions.
- Erika Check Hayden
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News Feature |
Evolution: Revenge of the hopeful monster
Experiments have revealed how single mutations can have huge effects that drive evolution. But small steps pave the way, finds Tanguy Chouard.
- Tanguy Chouard
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Article |
The primary transcriptome of the major human pathogen Helicobacter pylori
The transcriptome of Helicobacter pylori, an important human pathogen involved in gastric ulcers and cancer, is presented. The approach establishes a model for mapping and annotating the primary transcriptomes of many living species.
- Cynthia M. Sharma
- , Steve Hoffmann
- & Jörg Vogel
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Letter |
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
Here, iPS cell technology is used to study the mechanisms underlying dyskeratosis congenita in humans. Reprogramming restores telomere elongation in dyskeratosis congenita cells despite genetic lesions affecting telomerase. The reprogrammed cells were able to overcome a critical limitation in telomerase RNA component (TERC) levels to restore telomere maintenance and self-renewal, and multiple telomerase components are targeted by pluripotency-associated transcription factors.
- Suneet Agarwal
- , Yuin-Han Loh
- & George Q. Daley
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Article |
Remarkably ancient balanced polymorphisms in a multi-locus gene network
Local adaptations are often governed by several interacting genes scattered throughout the genome. Here a novel type of multi–locus genetic variation is described that has been maintained within a species over a vast period of time. A balanced unlinked gene network polymorphism is dissected that involves galactose utilization in a close relative of baker's yeast.
- Chris Todd Hittinger
- , Paula Gonçalves
- & Antonis Rokas
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Article
| Open AccessAncient human genome sequence of an extinct Palaeo-Eskimo
The first genome sequence of an ancient human is reported. It comes from an approximately 4,000-year-old permafrost-preserved hair from a male from the first known culture to settle in Greenland. Functional single-nucleotide polymorphism (SNP) assessment is used to assign possible phenotypic characteristics and high-confidence SNPs are compared to those of contemporary populations to find those most closely related to the individual.
- Morten Rasmussen
- , Yingrui Li
- & Eske Willerslev
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Article |
Genome sequencing and analysis of the model grass Brachypodium distachyon
The genome of the wild grass Brachypodium distachyon (Brachypodium), a member of the Pooideae subfamily, is sequenced. The Pooideae are one of three subfamilies of grasses that provide the bulk of human nutrition and may become major sources of renewable energy. Availability of the genome sequence should help establish Brachypodium as a model for developing new energy and food crops.
- John P. Vogel
- , David F. Garvin
- & Ivan Baxter
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News & Views |
50 & 100 years ago
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News |
Genetic basis for stuttering identified
Mutations found in genes responsible for directing enzymes to their cellular destination.
- Janet Fang
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News |
DNA secrets of the ice hair
First ancient human genome sheds light on origins of Arctic people.
- Rex Dalton
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News & Views |
Face of the past reconstructed
DNA is particularly well preserved in hair — enabling the genome of a human to be sequenced, and his ancestry and appearance to be determined, from 4,000-year-old remains.
- David M. Lambert
- & Leon Huynen
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Authors |
Constantin Polychronakos & Michael German
Projects converge on gene central to formation of insulin-producing cells.
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News & Views |
Mitochondrial damage control
Defects in mitochondria are implicated in Parkinson's disease. Study of a quality-control pathway involving the proteins PINK1 and Parkin provides further clues about the mechanism involved.
- Asa Abeliovich
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News Feature |
Palaeogenetics: Icy resolve
Eske Willerslev combines Arctic escapades with meticulous lab work in his quest to pull ancient DNA from the ice. Rex Dalton talks to the adventurer about extracting the first ancient human genome.
- Rex Dalton
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Letter |
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
Recently, numerous single nucleotide polymorphisms have been identified as being associated with obesity, but these loci together account for only a small fraction of the known heritable component. Here, an association is reported between rare deletions of at least 593 kilobases at 16p11.2 and a highly penetrant form of obesity. The strategy used of combining study of extreme phenotypes with targeted follow-up is promising for identifying missing heritability in obesity.
- R. G. Walters
- , S. Jacquemont
- & J. S. Beckmann
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Editorial |
Time for the epigenome
The complexity of genetic regulation is one of the great wonders of nature, but it represents a daunting challenge to unravel. The International Human Epigenome Consortium is an appropriate response.
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Letter |
CHD7 cooperates with PBAF to control multipotent neural crest formation
Heterozygous mutations in the gene encoding CHD7, an ATP-dependent chromatin-remodelling protein, result in CHARGE syndrome — a disorder characterized by malformations of the craniofacial structures, peripheral nervous system, ears, eyes and heart. In humans and Xenopus, CHD7 is now shown to be essential for the formation of multipotent migratory neural crest and for activating the transcriptional circuitry of the neural crest; shedding light on the pathoembryology of CHARGE syndrome.
- Ruchi Bajpai
- , Denise A. Chen
- & Joanna Wysocka
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News |
Project set to map marks on genome
Consortium sets sights on the differences that make us different.
- Alison Abbott
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Article |
Retroviral intasome assembly and inhibition of DNA strand transfer
The integrase protein of retroviruses such as HIV-1 catalyses insertion of the viral genome into that of the host. Here, the long-awaited structure of the full-length integrase complex is predicted, revealing not only details of the biochemistry of the integration reaction, but also the means by which current inhibitors affect this process.
- Stephen Hare
- , Saumya Shree Gupta
- & Peter Cherepanov
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Research Highlights |
Genetics: Protein's billion-year history
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News |
Hiding place for missing heritability uncovered
Rare mutations linked to disease may hide in common variants.
- Brendan Maher
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Letter |
Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen
Although cyclin D1 is frequently overexpressed in human cancers, the full range of its functions in normal development and oncogenesis is unclear. Here, tagged cyclin D1 knock-in mouse strains are developed to allow a search for cyclin D1-binding proteins in different mouse organs using high-throughput mass spectrometry. The results show that, in addition to its established cell cycle roles, cyclin D1 has an in vivo transcriptional function in mouse development.
- Frédéric Bienvenu
- , Siwanon Jirawatnotai
- & Piotr Sicinski
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Letter |
Mutational robustness can facilitate adaptation
If robustness is the opposite of evolvability, we might expect that a robust population would have difficulty adapting to environmental change; however, some studies have suggested that genetic robustness facilitates adaptation. Here, using a general population genetics model, mutational robustness is found to either impede or facilitate adaptation depending on the population size, the mutation rate and the structure of the fitness landscape.
- Jeremy A. Draghi
- , Todd L. Parsons
- & Joshua B. Plotkin
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Letter |
FOXO-dependent regulation of innate immune homeostasis
Antimicrobial peptides (AMPs) are an important class of immune effector molecules which fight pathogen infections. AMP induction in Drosophila is regulated through the activation of the Toll and immune deficiency pathways; it is now shown that AMP activation can be achieved independently of these pathways by the transcription factor FOXO. In non-infected animals, AMP genes are activated in response to nuclear FOXO activity when induced by starvation.
- Thomas Becker
- , Gerrit Loch
- & Michael Hoch
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Research Highlights |
Evolutionary biology: Sperm signals
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Research Highlights |
Neuropharmacology: Beating depression
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Research Highlights |
Evolutionary biology: How girls go solo
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News & Views |
Decoding a national treasure
The giant-panda genome is the first reported de novo assembly of a large mammalian genome achieved using next-generation sequencing methods. The feat reflects a trend towards ever-decreasing genome-sequencing costs.
- Kim C. Worley
- & Richard A. Gibbs
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News |
Genomics boosts brain-cancer work
Molecular findings start to open up avenues of diagnosis and treatment.
- Erika Check Hayden
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Books & Arts |
Vision of a personal genomics future
The director of the US National Institutes of Health, Francis Collins, calls for a revolution in personalized medicine. Such advances should be shared beyond the developed world, says Abdallah S. Daar.
- Abdallah S. Daar
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News & Views |
New take on the Red Queen
Biologists have assumed that natural selection shapes larger patterns of evolution through interactions such as competition and predation. These patterns may instead be determined by rare, stochastic speciation.
- Michael J. Benton
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News |
Bacterial clocks chime in unison
Genetic circuit allows entire colonies to keep time.
- Erika Check Hayden
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News |
Lemurs' wet and wild past
Model shows how mammals could have 'rafted' to Madagascar.
- Geoff Brumfiel
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Letter |
Competition drives cooperation among closely related sperm of deer mice
Sperm can increase their swimming velocity and gain a competitive advantage over sperm from another male by forming cooperative groups, such that selection should favour cooperation of the most closely related sperm. Sperm of deer mice are now shown to aggregate more often with conspecific than heterospecific sperm, in accordance with this theory, whereas in a monogamous species lacking sperm competition, sperm indiscriminately group with unrelated conspecific sperm.
- Heidi S. Fisher
- & Hopi E. Hoekstra
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News |
Mystery of the brown giant panda deepens
Rare sighting of brown-and-white panda sparks conservation debate.
- Henry Nicholls
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Letter |
KAP1 controls endogenous retroviruses in embryonic stem cells
Much of the mammalian genome is derived from retroelements, a significant proportion of which are endogenous retroviruses (ERVs). ERVs are transcriptionally silenced during early embryogenesis by histone and DNA methylation, but the initiators of this process are largely unknown. Here, deletion of KAP1 is shown to lead to a marked upregulation of a range of ERVs in mouse embryonic stem cells and in early embryos.
- Helen M. Rowe
- , Johan Jakobsson
- & Didier Trono
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Article
| Open AccessGenome sequence of the palaeopolyploid soybean
Soybean is an important crop plant, providing seed protein and oil and fixing atmospheric nitrogen through symbioses with soil-borne microorganisms. Using a whole-genome shotgun approach, its 1.1-gigabase genome is now sequenced and integrated with physical and high-density genetic maps to create a chromosome-scale draft sequence assembly.
- Jeremy Schmutz
- , Steven B. Cannon
- & Scott A. Jackson
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Research Highlights |
Immunology: Double punch for HIV
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Research Highlights |
Molecular biology: Flowering time unravelled
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