Gastrointestinal models articles within Nature Materials

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  • Article |

    The influence of stress relaxation of the extracellular matrix on the formation of intestinal organoids was investigated. It was shown that a stress-relaxing synthetic matrix promotes crypt budding through increased symmetry breaking and niche cell formation.

    • Antonius Chrisnandy
    • , Delphine Blondel
    •  & Matthias P. Lutolf

  • News & Views |

    An immune cell population enriched in inflamed gut tissue is shown to play a role in driving CD44+ intestinal organoid proliferation, while also regulating extracellular matrix deposition and remodelling in a synthetic hydrogel platform.

    • Bauer L. LeSavage
    •  & Sarah C. Heilshorn

  • News & Views |

    A bioprinting approach that utilizes organoid-forming stem cells as a living ink within hydrogels guides tissue-scale self-organization to generate more realistic gastrointestinal and vascular tissue constructs.

    • Zev J. Gartner
    •  & Jennifer L. Hu

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