Featured
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Review Article |
Rethinking organoid technology through bioengineering
This Review provides an overview of bioengineering technologies that can be harnessed to facilitate the culture, self-organization and functionality of human pluripotent stem cell-derived organoids.
- Elena Garreta
- , Roger D. Kamm
- & Nuria Montserrat
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Article |
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells
A method to accelerate the generation of kidney organoids from human pluripotent stem cells cultured in a three-dimensional environment and exposed to inductive stimuli has been developed, with the organoids capable of recapitulating kidney organogenesis.
- Elena Garreta
- , Patricia Prado
- & Nuria Montserrat
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Article |
Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells
Mechanical cues play critical roles in embryonic development. A micropatterned neuroectoderm developmental model based on human pluripotent stem cells now reveals how morophogenetic signals such as cell shape and contractility regulate neural tissue development.
- Xufeng Xue
- , Yubing Sun
- & Jianping Fu
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News & Views |
Auxetic nuclei
The nuclei of naive mouse embryonic stem cells that are transitioning towards differentiation expand when the cells are stretched and contract when they are compressed. What drives this auxetic phenotype is, however, unclear.
- Ning Wang
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News & Views |
Stressed-out stem cells
Experiments have shown that the physical characteristics of the matrix surrounding a stem cell can affect its behaviour. This picture gets further complicated by studies of stem cells and their differentiated counterparts that show that the cells' own softness also has a clear role in how they respond to stress.
- Andrew W. Holle
- & Adam J. Engler
Stem-cell-based embryo models for fundamental research and translation