Featured
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News & Views |
Nanocages for virus inhibition
Elaborately designed DNA icosahedral shells cage intact virions to effectively protect host cells from viral infections.
- Neha Chauhan
- & Xing Wang
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News & Views |
Long-acting antiretroviral therapy
Nanoformulations of cabotegravir prodrugs have been developed to prolong the pharmacokinetics of the antiretroviral agent. They can be present in the plasma of mice and non-human primates for a year following a single injection.
- Vicente Soriano
- , Pablo Barreiro
- & Carmen de Mendoza
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Article |
Taxanes convert regions of perturbed microtubule growth into rescue sites
Anticancer drugs such as Taxol can affect microtubule dynamics and organization in cells. Direct visualization of the action of such drugs has shown that they can trigger local and cooperative changes in microtubule lattice and induce formation of stable microtubule regions that promote rescues.
- Ankit Rai
- , Tianyang Liu
- & Anna Akhmanova
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News & Views |
Targeting vesicle size
An amphipathic peptide has been engineered and is capable of penetrating the blood–brain barrier as well as possessing a potent antiviral activity against Zika and other mosquito-borne viruses.
- Jing Zou
- & Pei-Yong Shi
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Letter |
Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide
The Zika virus infects the central nervous system and results in severe brain malformation. An amphiphatic peptide is now shown to penetrate the blood–brain barrier, reducing viral loads due to its activity against Zika and other mosquito-borne viruses.
- Joshua A. Jackman
- , Vivian V. Costa
- & Nam-Joon Cho
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News & Views |
Broad-spectrum antivirals
Nanoparticle mimics of heparan sulfate proteoglycans offer a new strategy for the inhibition of a range of viral infections.
- Benson J. Edagwa
- & Howard E. Gendelman
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Article |
Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism
Antiviral nanoparticle-formulated mimics of heparan sulfate proteoglycans were developed and shown to permit strong viral association as well as inhibition of a range of viruses on in vitro and in vivo models of infection.
- Valeria Cagno
- , Patrizia Andreozzi
- & Francesco Stellacci
Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung