Correspondence |
Featured
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News |
Anti-ageing protein injection boosts monkeys’ memories
First primate studies to show cognitive benefits of the protein klotho could be a step towards clinical applications.
- Lilly Tozer
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News |
Australia to prescribe MDMA and psilocybin for PTSD and depression in world first
Decision to make the previously illicit drugs available is dogged by suggestions that it was rushed.
- Rich Haridy
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Outlook |
Battling a health crisis in the Amazon
Scientists are racing to control malaria in northern Brazil where the disease is playing a major part in the current health emergency threatening the region’s Indigenous people.
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Outlook |
The challenges facing scientists in the elimination of malaria
The world now has a malaria vaccine, but it won’t be enough to wipe out the parasitic disease
- Richard Hodson
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News |
Promising tuberculosis vaccine gets US$550-million shot in the arm
The candidate is moving to long-awaited phase III trials — if successful, it would be the first new jab against the disease in more than 100 years.
- Lilly Tozer
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Outlook |
Malaria’s modelling problem
Southern Africa wants to eliminate the disease by 2030, but predicting where and when the disease will strike remains a challenge.
- Linda Nordling
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Outlook |
Can malaria researchers slow the spread of drug resistance?
Concerns that artemisinin combination treatments are losing their effectiveness against Plasmodium parasites have set scientists looking for alternatives.
- T. V. Padma
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Outlook |
The next frontier for malaria vaccination
Hot on the heels of the first approved vaccine for malaria, researchers are racing to develop even better shots that tackle the parasite at every stage of its life cycle.
- Cassandra Willyard
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Outlook |
Malaria: highlights from research
A mosquito hibernation mystery solved, parasites grown in dishes for the first time, and other studies and trials.
- Laura Vargas-Parada
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Outlook |
In search of a vaccine for Plasmodium vivax malaria
Vaccinologist Arturo Reyes-Sandoval explains how researchers are edging closer to a much-needed vaccine.
- Laura Vargas-Parada
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Outlook |
Monoclonal antibodies show promise for malaria prevention
Immunologist Robert Seder and malaria epidemiologist Kassoum Kayentao talk to Nature about their work and how they think the parasitic disease could be controlled in the future.
- Cassandra Willyard
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Outlook |
How genetically modified mosquitoes could eradicate malaria
Gene-drive technology that can spread antimalarial modifications throughout mosquito populations is maturing, but there are questions to answer before it can be used in the wild.
- Sam Jones
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Research Briefing |
Energy burn in muscle boosted by a hormonal signalling axis
Restricting dietary calories leads to weight loss, but with time these effects diminish because the body’s metabolism slows down. A hormone called GDF15 is now shown to maintain weight loss during dieting by promoting energy expenditure through the activation of pathways that affect calcium levels in skeletal muscle.
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Article
| Open AccessGDF15 promotes weight loss by enhancing energy expenditure in muscle
GDF15 treatment in mice counteracts compensatory reductions in energy expenditure, resulting in greater weight loss and reductions in non-alcoholic fatty liver disease compared to caloric restriction alone.
- Dongdong Wang
- , Logan K. Townsend
- & Gregory R. Steinberg
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Article |
Locus for severity implicates CNS resilience in progression of multiple sclerosis
A genome-wide association study including 22,389 cases of multiple sclerosis finds an association with disease progression at the DYSF–ZNF638 and DNM3–PIGC loci and identifies a potential of higher educational attainment in slowing disease progression.
- Adil Harroud
- , Pernilla Stridh
- & Kári Stefánsson
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Correspondence |
Autism: don’t negate the value of applied behaviour analysis
- Gina Green
- , Russell Lang
- & Jason Travers
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News |
Beyond Ozempic: brand-new obesity drugs will be cheaper and more effective
Hormone mimics offer advantages even beyond those of the potent weight-loss jabs on the market now.
- Saima Sidik
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Spotlight |
By the numbers: China’s changing diet
Data show that the Chinese middle class is eating a higher-fat, less-healthy diet — a trend reflected in the increases in heart disease and childhood obesity.
- Yvaine Ye
- & Jack Leeming
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Article |
Y chromosome loss in cancer drives growth by evasion of adaptive immunity
Loss of the Y chromosome in tumour cells is associated with a poor prognosis for patients with bladder cancer by causing local T cell exhaustion, which also increases the response to immune checkpoint blockade therapy.
- Hany A. Abdel-Hafiz
- , Johanna M. Schafer
- & Dan Theodorescu
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News |
Mum’s microbes might boost brain development of c-section babies
Vaginal seeding is safe and seems to benefit infants delivered by the surgery — but larger trials are needed.
- Ewen Callaway
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Spotlight |
Mapping the Chinese microbiome: it’s time for a united effort
Much has been done to investigate the human microbiome. Now, it’s time for countries to dig deeper.
- Ju-Sheng Zheng
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News |
Concussion guidance for sport sidesteps link to brain disease — critics are baffled
The statement’s authors say the connection between repeated head injuries and the condition CTE is based on insufficiently rigorous data.
- Katharine Sanderson
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News |
How psychedelic drugs achieve their potent health benefits
Mouse studies suggest that drugs from LSD to ecstasy renew the brain’s flexibility — but some scientists are sceptical.
- Sara Reardon
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News |
Could endometriosis be caused by bacteria? Study offers fresh clues
Link to bacterial infection suggests a potential way to treat the painful disorder.
- Heidi Ledford
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Outlook |
Brain-zapping technology helps smokers to quit
Repetitive transcranial magnetic stimulation is already approved to help people overcome addiction to cigarettes, but researchers still have a lot to learn about how to deliver the treatment effectively.
- Simon Makin
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News |
Does shingles vaccination cut dementia risk? Large study hints at a link
Analysis of nearly 300,000 people finds an association between the shingles jab and a lower rate of dementia — but questions linger.
- Sara Reardon
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Article
| Open AccessAxonemal structures reveal mechanoregulatory and disease mechanisms
Detailed atomic models of axonemes from algal flagella and human respiratory cilia, which are hair-like protrusions from cells that enable motility and clear mucus from human airways, could provide insights into how they function.
- Travis Walton
- , Miao Gui
- & Alan Brown
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Article |
Transfer learning enables predictions in network biology
A context-aware, attention-based deep learning model pretrained on single-cell transcriptomes enables predictions in settings with limited data in network biology and could accelerate discovery of key network regulators and candidate therapeutic targets.
- Christina V. Theodoris
- , Ling Xiao
- & Patrick T. Ellinor
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Comment |
Why the world needs more transparency on the origins of novel pathogens
Collaboration and openness are essential to minimize the risks of future pandemics, says the World Health Organization’s scientific advisory group, SAGO.
- Marietjie Venter
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News |
US will vaccinate birds against avian flu for first time — what researchers think
The country plans to vaccinate endangered condors in an effort to curb unprecedented H5N1 outbreaks.
- Max Kozlov
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Outlook |
RNA splicing targets age-related diseases
Manipulating genetic molecules could return cells to a younger state.
- Christine Evans-Pughe
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Article
| Open AccessHeteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy
The membrane-shaping protein ARL6IP1 is involved in the selective degradation of the endoplasmic reticulum, and this process depends on its ubiquitination and interaction with other membrane-shaping proteins such as FAM134B.
- Hector Foronda
- , Yangxue Fu
- & Christian A. Hübner
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News |
Game-changing obesity drugs go mainstream: what scientists are learning
Studies tackle who’s most likely to lose weight on the new generation of anti-obesity medications.
- Mariana Lenharo
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Technology Feature |
Brain imaging: fMRI advances make scans sharper and faster
Researchers are finding ways to improve one of neuroscientists’ favourite tools: functional magnetic resonance imaging.
- Diana Kwon
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News |
‘The disease will be neglected’: scientists react to the WHO ending mpox emergency
Researchers worry that certain regions, including Africa, will suffer if global attention moves away from the outbreak.
- Layal Liverpool
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News Feature |
‘I am not a broken version of normal’ — autistic people argue for a stronger voice in research
Despite broader acceptance of neurodiversity, autistic advocates and scientists are still fighting for a chance to set clinical and scientific priorities.
- Emiliano Rodríguez Mega
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Article
| Open AccessPan-cancer whole-genome comparison of primary and metastatic solid tumours
The genomic differences between primary and metastatic tumours are assessed across 23 cancer types using pan-cancer whole-genome analysis.
- Francisco Martínez-Jiménez
- , Ali Movasati
- & Arne Van Hoeck
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News Feature |
Is the world ready for ChatGPT therapists?
The current landscape of mobile mental-health apps is the result of a 70-year search to automate therapy. Now, advanced AIs pose fresh ethical questions.
- Ian Graber-Stiehl
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Comment |
Address the growing urgency of fungal disease in crops
More political and public awareness of the plight of the world’s crops when it comes to fungal disease is crucial to stave off a major threat to global food security.
- Eva Stukenbrock
- & Sarah Gurr
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News |
Racial inequalities deepened in US prisons during COVID
The proportion of incarcerated people who were Black or Latino increased during the pandemic, mainly because of sentencing differences.
- Myriam Vidal Valero
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News Feature |
US could soon approve MDMA therapy — opening an era of psychedelic medicine
Perceptions have shifted dramatically in the past few years on the therapeutic value of illicit drugs such as ecstasy. But questions still linger about what FDA approval might look like.
- Sara Reardon
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Book Review |
Did the Black Death break feudalism and make capitalism? Maybe, maybe not
Pathogens and pandemics have played a huge part in shaping human history right up to COVID-19 — but their exact effects remain highly debatable.
- Hugh Pennington
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News Explainer |
Hotly anticipated ALS drug could pave way for more brain treatments
A thumbs-up for tofersen from the US Food and Drug Administration would reinforce the agency’s shifting approach to neurological drugs.
- Asher Mullard
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Outlook |
Kids and clinical trials: why the system is failing children
A panel of physicians and researchers discusses the reasons for the paucity of trials, the effect it has on patients and how the approval process for paediatric drugs could be streamlined.
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News |
Massive mosquito factory in Brazil aims to halt dengue
Facility will produce up to five billion bacteria-infected mosquitoes per year.
- Mariana Lenharo
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Article |
Clonal haematopoiesis and risk of chronic liver disease
A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.
- Waihay J. Wong
- , Connor Emdin
- & Pradeep Natarajan
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Article
| Open AccessAstrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms
Analyses of the proteomes of astrocytes and neurons in a cell-specific and subcompartment-specific manner reveal distinct roles for these cell types that are relevant to obsessive–compulsive disorder and perhaps other brain disorders.
- Joselyn S. Soto
- , Yasaman Jami-Alahmadi
- & Baljit S. Khakh
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News |
Wheat disease’s global spread concerns researchers
Genomic analysis reveals that the wheat blast fungus spread independently from South America to two other continents.
- Ewen Callaway
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