Deoxy sugars articles within Nature Communications

Featured

• Article
  01 February 2019 | Open Access

  Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms

  Mother Nature is a valuable resource for the discovery of drug and agricultural chemicals. Here, the authors show that 7-deoxy-sedoheptulose produced by a cyanobacterium is an antimicrobial and herbicidal compound that acts through inhibition of 3-dehydroquniate synthase in the shikimate pathway.

  • Klaus Brilisauer
  • , Johanna Rapp
  •  & Karl Forchhammer

• Article
  19 November 2018 | Open Access

  Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes

  Bacillus anthracis causes the infectious disease anthrax. Here, the authors synthesized deoxy glycosides that are effective against B. anthracis and related bacteria and found that these amphiphilic compounds kill bacteria via an unusual mechanism of action.

  • Catarina Dias
  • , João P. Pais
  •  & Amélia P. Rauter

• Article
  09 November 2018 | Open Access

  A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates

  Polyfluorinated hexopyranoses display unique physical, chemical and biological properties, however their stereoselective synthesis is highly challenging. Here, the authors report a synthetic approach based on the chemical manipulation of inexpensive levoglucosan to obtain heavily fluorinated monosaccharides stereoselectively.

  • Vincent Denavit
  • , Danny Lainé
  •  & Denis Giguère