Article
|
Open Access
Featured
-
-
Letter |
Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis
Circadian circuits, entrained by light and tuned by the brain, regulate intestinal group 3 innate lymphoid cells in mice, along with epithelial reactivity, microbiome composition and lipid metabolism.
- Cristina Godinho-Silva
- , Rita G. Domingues
- & Henrique Veiga-Fernandes
-
Article
| Open Access
The genomic basis of circadian and circalunar timing adaptations in a midge
Genomic and molecular analyses of Clunio marinus timing strains suggest that modulation of alternative splicing of Ca2+/calmodulin-dependent kinase II represents a mechanism for evolutionary adaptation of circadian timing.
- Tobias S. Kaiser
- , Birgit Poehn
- & Kristin Tessmar-Raible
-
Article |
Circadian neuron feedback controls the Drosophila sleep–activity profile
A subset of dorsal clock neurons are identified in Drosophila as sleep-promoting cells, which participate in a feedback loop with pacemaker neurons to drive both midday siesta and night-time sleep.
- Fang Guo
- , Junwei Yu
- & Michael Rosbash
-
Letter |
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
The nuclear receptors REV-ERB-α and REV-ERB-β are indispensible for the coordination of circadian rhythm and metabolism; mice without these nuclear receptors show disrupted circadian expression of core circadian clock and lipid homeostatic gene networks.
- Han Cho
- , Xuan Zhao
- & Ronald M. Evans
-
Article |
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
Synthetic REV-ERB agonists can alter the circadian expression of core clock genes in the hypothalami of mice, which changes the expression of metabolic genes in liver, skeletal muscle and adipose tissue, and results in increased energy expenditure.
- Laura A. Solt
- , Yongjun Wang
- & Thomas P. Burris
-
Letter |
The novel gene twenty-four defines a critical translational step in the Drosophila clock
Gene expression fluctuates in concert with the day/night cycle, and this results in differential behaviours throughout the day. These changes in expression have been studied at the transcriptional and post-translational levels. Here, another type of circadian-influenced regulation that occurs at the post-transcriptional level is defined. The twenty-four (TYF) protein associates with the mRNA of the clock protein PER, enhancing its translation.
- Chunghun Lim
- , Jongbin Lee
- & Joonho Choe
-
Research Highlights |
Neuroscience: Brain connections have rhythm
-
-
Letter |
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Circadian rhythms control many physiological functions. During periods of feeding, pancreatic islets secrete insulin to maintain glucose homeostasis — a rhythmic process that is disturbed in people with diabetes. These authors show that pancreatic islets contain their own clock: they have self-sustained circadian oscillations of CLOCK and BMAL1 genes and proteins, which are vital for the regulation of circadian rhythms. Without this clock, a cascade of cellular failure and pathology initiates the onset of diabetes mellitus.
- Biliana Marcheva
- , Kathryn Moynihan Ramsey
- & Joseph Bass
A single photoreceptor splits perception and entrainment by cotransmission