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| Open AccessOrganocatalyst treatment improves variant calling and mutant detection in archival clinical samples
- Leah C. Wehmas
- , Charles E. Wood
- & Susan D. Hester
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| Open AccessA genome-wide portrait of pervasive drug contaminants
- Joseph Uche Ogbede
- , Guri Giaever
- & Corey Nislow
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| Open AccessA survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics
- Jessica Knox
- , Nicolas Joly
- & Peter J. Roy
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| Open AccessComparing the protective effects of resveratrol, curcumin and sulforaphane against LPS/IFN-γ-mediated inflammation in doxorubicin-treated macrophages
- Haidy A. Saleh
- , Eman Ramdan
- & Anwar Abdelnaser
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Article
| Open AccessMetampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde
- Raphael Reinbold
- , Tobias John
- & Richard J. Hopkinson
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| Open AccessChemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance
- Nitika
- , Jacob S. Blackman
- & Andrew W. Truman
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| Open AccessMechanistic insights on the mode of action of an antiproliferative thiosemicarbazone-nickel complex revealed by an integrated chemogenomic profiling study
- Enrico Baruffini
- , Roberta Ruotolo
- & Tiziana Lodi
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| Open AccessStriking essential oil: tapping into a largely unexplored source for drug discovery
- Adam F. Feyaerts
- , Walter Luyten
- & Patrick Van Dijck
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Article
| Open AccessFarnesoid X receptor and bile acids regulate vitamin A storage
- Ali Saeed
- , Jing Yang
- & Klaas Nico Faber
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| Open AccessPlant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathway
- Vivek Halder
- , Mohamed N. S. Suliman
- & Markus Kaiser
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Article
| Open AccessChloramphenicol inhibits eukaryotic Ser/Thr phosphatase and infection-specific cell differentiation in the rice blast fungus
- Akihito Nozaka
- , Ayaka Nishiwaki
- & Takashi Kamakura
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Article
| Open AccessHDAC Regulates Transcription at the Outset of Axolotl Tail Regeneration
- S. Randal Voss
- , Larissa V. Ponomareva
- & Jon S. Thorson
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Article
| Open AccessHypoculoside, a sphingoid base-like compound from Acremonium disrupts the membrane integrity of yeast cells
- Mohammad Alfatah
- , Jin Huei Wong
- & Prakash Arumugam
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| Open AccessA chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals
- Michael D. Rugen
- , Mathieu M. J. L. Vernet
- & Robert A. Field
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Article
| Open AccessAn enhanced C. elegans based platform for toxicity assessment
- Huajiang Xiong
- , Catherine Pears
- & Alison Woollard
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Article
| Open AccessEvolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation
- Ayumi Yamagami
- , Chieko Saito
- & Takeshi Nakano
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Article
| Open AccessA quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B
- Shohei Takase
- , Rumi Kurokawa
- & Ken Matsumoto
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Article
| Open AccessOccurrence of fibrates and their metabolites in source and drinking water in Shanghai and Zhejiang, China
- Akiko Ido
- , Youhei Hiromori
- & Tsuyoshi Nakanishi
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Article
| Open AccessIdentification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells
- David Estoppey
- , Jeffrey W. Hewett
- & Dominic Hoepfner
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Article
| Open AccessCombined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model
- Upendarrao Golla
- , Deepthi Joseph
- & Raghuvir Singh Tomar
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Article
| Open AccessSite-specific fluorescent labeling to visualize membrane translocation of a myristoyl switch protein
- Sung-Tae Yang
- , Sung In Lim
- & Lukas K. Tamm
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Article
| Open AccessCombretastatin A-4 efficiently inhibits angiogenesis and induces neuronal apoptosis in zebrafish
- Yun-Wei Shi
- , Wei Yuan
- & Dong Liu
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| Open AccessThe nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome
- Philippa H. Harlow
- , Simon J. Perry
- & Anthony J. Flemming
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| Open AccessPterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain
- Ting Dong
- , Weilong Liu
- & Xiaoguang Lei
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| Open AccessExistence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy
- Libo Yuan
- , Tian Tian
- & Xiang Zhou
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Article
| Open AccessImprimatinC1, a novel plant immune-priming compound, functions as a partial agonist of salicylic acid
- Yoshiteru Noutoshi
- , Yusuke Jikumaru
- & Ken Shirasu
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| Open AccessA synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts
- Ganesh N. Pandian
- , Yusuke Nakano
- & Hiroshi Sugiyama