Catalytic DNA articles within Nature Communications

Featured

• Article
  17 May 2024 | Open Access

  The 8-17 DNAzyme can operate in a single active structure regardless of metal ion cofactor

  Here, the authors use solution-state NMR to characterize the structure of 8–17 DNAzyme, revealing that all metal cofactors induce the same DNAzyme fold in contrast to previous findings.

  • Julia Wieruszewska
  • , Aleksandra Pawłowicz
  •  & Witold Andrałojć

• Article
  16 November 2022 | Open Access

  XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection

  RNA viruses have been responsible for large-scale epidemics and pandemics throughout the last few centuries. Here, the authors show the design, synthesis and screening of artificial RNA endonuclease XNAzymes capable of cleaving genomic SARS-CoV-2 RNA and self-assembling into enzymatic nanostructures inhibiting cellular viral replication.

  • Pehuén Pereyra Gerber
  • , Maria J. Donde
  •  & Alexander I. Taylor

• Article
  18 January 2019 | Open Access

  Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions

  Most approaches to control gene expression in vivo require generation of knock-in mouse lines and often lack spatiotemporal control. Here the authors develop a photo-activatable Flp recombinase system and demonstrate its use by controlling object-exploration behavior in mice through Cav3.1 silencing.

  • Hyunjin Jung
  • , Seong-Wook Kim
  •  & Won Do Heo