Featured
-
-
Article
| Open AccessHypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts
Smoking tobacco is known to alter DNA methylation. Here, the authors show that hypomethylation of smoke-related genes is associated with future increase in lung cancer risk.
- Francesca Fasanelli
- , Laura Baglietto
- & Paolo Vineis
-
Article
| Open AccessLarge-scale association analysis in Asians identifies new susceptibility loci for prostate cancer
Genetic variations influence the risk of prostate cancer. Here, the authors use a meta-analysis of Genome-wide association studies from Asian populations and uncover new susceptibility loci at 11p15.4 and 14q23.2.
- Meilin Wang
- , Atsushi Takahashi
- & Jianfeng Xu
-
Article |
Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Previous studies have shown that both rare pathogenic mutations and common genetic variants contribute to the familial risk of developing colorectal cancer. Here, the authors carry out a two-stage genome-wide association study and identify six new loci associated with colorectal cancer.
- Fredrick R. Schumacher
- , Stephanie L. Schmit
- & Ulrike Peters
-
Article |
Variation in genomic landscape of clear cell renal cell carcinoma across Europe
Renal cancer accounts for 2.4% of all adult cancers and its incidence is increasing worldwide. Here, the authors carry out genome and transcriptome sequencing of clear cell renal cell carcinomas (ccRCCs) and highlight genomic aberrations and biological pathways underlying ccRCC tumorigenesis.
- Ghislaine Scelo
- , Yasser Riazalhosseini
- & G. Mark Lathrop
-
Article |
Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide and genetic susceptibility to the disease is poorly understood. Here, the authors combine data from Japanese, African American and European samples and identify a common variant in VTI1Athat increases CRC risk across all populations.
- Hansong Wang
- , Terrilea Burnett
- & Loïc Le Marchand