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| Open AccessAged bone matrix-derived extracellular vesicles as a messenger for calcification paradox
This study uncovers the role of extracellular vesicles from bone matrix as a messenger in the development of osteoporosis and vascular calcification (calcification paradox) during skeletal aging and menopause by transferring miR-483-5p and miR-2861.
- Zhen-Xing Wang
- , Zhong-Wei Luo
- & Hui Xie
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| Open AccessInhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers
Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate crystallization and inhibits soft tissue calcification in vivo following subcutaneous injection.
- Antonia E. Schantl
- , Anja Verhulst
- & Jean-Christophe Leroux
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Article
| Open AccessPoly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
Vascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by suppressing miR-204 expression via IL-6/STAT3 signaling, thus relieving repression of the osteogenic regulator Runx2.
- Cheng Wang
- , Wenjing Xu
- & Kai Huang
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Article
| Open AccessMDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
Vascular calcification (VC) increases morbidity and mortality in cardiovascular and metabolic diseases. Here, Kwon et al.show that calcification stimuli induce MDM2- mediated ubiquitination and proteasomal degradation of HDAC1, suggesting a possible therapeutic strategy for treatment of VC patients.
- Duk-Hwa Kwon
- , Gwang Hyeon Eom
- & Hyun Kook
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Article
| Open AccessENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
Generalized arterial calcification of infancy (GACI) is a terminal disease caused by the ENPP1 enzyme deficiency. Here, Albrigh et al. show that ENPP1 enzyme replacement therapy prevents the ectopic calcifications and mortality in mice with GACI, suggesting a novel treatment for vascular calcification in humans.
- Ronald A. Albright
- , Paul Stabach
- & Demetrios T. Braddock
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| Open AccessIdentifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography
Atherosclerotic plaques with macrocalcification are stable, whereas microcalcification is a key feature of rupture-prone plaques. Here the authors show that18F-NaF PET/CT imaging can distinguish between macro- and microcalcification providing a potential, non-invasive imaging technique to identify patients with high-risk atheroma.
- Agnese Irkle
- , Alex T. Vesey
- & Anthony P. Davenport
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The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells
Vascular calcification is commonly associated with advanced stages of atherosclerosis. Woldtet al. show that the nuclear hormone receptor PPARγ in vascular smooth muscle cells protects mice from vascular calcification by inhibiting Wnt5a signalling triggered by activation of the cell-surface receptor LRP1.
- Estelle Woldt
- , Jérome Terrand
- & Philippe Boucher