News & Views |
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News & Views |
Injectable and retrievable soft electronics
Liquid bioelectronics based on a permanent fluidic magnet made from three-dimensional assembled magnetic colloidal particles can be injected into the surface of the heart for cardiovascular monitoring and subsequently retrieved after use.
- Jiahong Li
- , Yadong Xu
- & Wei Gao
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Article
| Open Access
Electrochemically actuated microelectrodes for minimally invasive peripheral nerve interfaces
Electrode arrays for neurological diagnosis and treatment carry a risk of nerve injury. Nerve cuffs with tiny voltage-controlled shape-reconfigurable electrode arrays have been reported, allowing active wrapping around delicate nerves.
- Chaoqun Dong
- , Alejandro Carnicer-Lombarte
- & George G. Malliaras
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Article |
An intelligent DNA nanodevice for precision thrombolysis
An intelligent DNA nanodevice, composed of DNA origami nanosheets and a thrombin-responsive DNA fastener, accurately delivers the appropriate dose of tissue plasminogen activator following activation by distinct thrombosis events.
- Jue Yin
- , Siyu Wang
- & Lianhui Wang
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Article |
Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells
Implants made from patient-derived lyophilized lymph nodes loaded with chimeric antigen receptor T cells improve T cell delivery and inhibit tumour recurrence.
- Jiaqi Shi
- , Wei Wu
- & Zhen Gu
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Article
| Open Access
Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Sequential drinks of crosslinker and polymer solutions form a tough hydrogel in the stomach, enabling delivery of drugs and biologics in this harsh chemical environment.
- Gary W. Liu
- , Matthew J. Pickett
- & Giovanni Traverso
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Article |
Pro-regenerative biomaterials recruit immunoregulatory dendritic cells after traumatic injury
Pro-regenerative biomaterials for the treatment of muscle injury induce the proliferation of a dendritic cell population associated with cross-presentation and self-tolerance, promoting a pro-regenerative immune environment to aid muscle wound healing.
- Ravi Lokwani
- , Aditya Josyula
- & Kaitlyn Sadtler
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Article |
Self-rectifying magnetoelectric metamaterials for remote neural stimulation and motor function restoration
Self-rectifying magnetoelectric metamaterials with nonlinear responses generate electrical pulse sequences that enable precisely timed remote neural stimulation and restoration of sensory motor responses in vivo.
- Joshua C. Chen
- , Gauri Bhave
- & Jacob T. Robinson
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News & Views |
Bioelectronics goes vertical
Remotely powered vertical electrochemical transistors are demonstrated to track subtle nerve-cell activity even when the transistor core is fully shielded from the biological environment.
- C. Eckel
- & R. T. Weitz
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News & Views |
Better electronics from immiscibility
A bicontinuous conducting polymer hydrogel with high electrical conductivity, stretchability and fracture toughness in physiological environments achieves high-fidelity monitoring and effective stimulation of tissues and organs.
- Youdi Liu
- , Faheem Ershad
- & Cunjiang Yu
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News & Views |
A defensive blanket against viral infection of the lungs
A safe, inhalable formulation of mucin-interacting hydrogel microparticles creates a dense protective network in the lungs against viral infections.
- Thomas Crouzier
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Article |
Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas
A hydrogel-based modular lymphoma organoid identifies how lymphoid microenvironment cues dampen the effect of MALT1 inhibitors and informs effective combination therapies to rescue the treatment response
- Shivem B. Shah
- , Christopher R. Carlson
- & Ankur Singh
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News & Views |
A bioadhesive robot to activate muscles
Soft actuators composed of a tough bioadhesive/elastomer shell encapsulating a stimuli-responsive metallic spring provide in situ mechanical stimulation of skeletal muscles to promote muscle tissue rehabilitation and prevent atrophy.
- Xuanhe Zhao
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Article |
Active tissue adhesive activates mechanosensors and prevents muscle atrophy
An implantable tissue adhesive soft actuator adheres to muscle, generating mechanical stimulation, and activates mechanosensing pathways for prevention of atrophy in disuse muscles.
- Sungmin Nam
- , Bo Ri Seo
- & David J. Mooney
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Article |
Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia
Biohybrid microrobots consisting of nanoparticle-modified microalgae are constructed for active drug delivery in the lungs. In an acute bacterial pneumonia model, the microrobots effectively reduce bacterial burden and lessen animal mortality.
- Fangyu Zhang
- , Jia Zhuang
- & Joseph Wang
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Article |
Transient nuclear deformation primes epigenetic state and promotes cell reprogramming
Mechanical confinement of fibroblasts into micrometre-sized channels deforms the cell nucleus, leading to temporary nuclear lamina destablization and disassembly, loss of lamina-associated domains in chromatin and a decrease in histone and DNA methylation. These mechanically induced alterations in chromatin boost the conversion of fibroblasts into neurons and pluripotent stem cells and thus can be explored for cell engineering applications.
- Yang Song
- , Jennifer Soto
- & Song Li
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Article |
Porosity-based heterojunctions enable leadless optoelectronic modulation of tissues
Fabrication of semiconductor heterojunctions typically involves a complex process and often leads to bioincompatibility. Here, the authors propose a porous heterojunction in p-type silicon via simple stain etching at ambient conditions, and apply it in optically induced biomodulation.
- Aleksander Prominski
- , Jiuyun Shi
- & Menahem Y. Rotenberg
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News & Views |
Toughness and elasticity from phase separation
A simple one-step method that enables the random copolymerization of two monomers with different solubility in ionic liquids creates phase-separated elastic and stiff domains that result in ultra-tough and stretchable ionogels.
- Gi Doo Cha
- & Dae-Hyeong Kim
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News & Views |
A photocurable bioelectronics–tissue interface
A functional bioadhesive has been developed to possess properties such as mechanical compliance, electrical conductivity and optical transparency, and is utilized for bonding electronic devices to various organs in the body for up to several months.
- Tsuyoshi Sekitani
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Letter |
Kirigami-inspired stents for sustained local delivery of therapeutics
A kirigami-inspired stent-based system has been developed for extended local drug delivery to the gastrointestinal and respiratory tracts as well as the vascular system.
- Sahab Babaee
- , Yichao Shi
- & Giovanni Traverso
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Review Article |
Sensory feedback for limb prostheses in amputees
This Review highlights the approaches that have been utilized in the implementation of sensory feedback onto prosthetic devices to restore the sensation of touch and proprioception for amputees.
- Stanisa Raspopovic
- , Giacomo Valle
- & Francesco Maria Petrini
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Article |
Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals
A magnetic torque actuator has been developed and is capable of modulation of neurons expressing the mechanosensitive ion channel, Piezo1, resulting in long-distance control of locomotion of mice.
- Jung-uk Lee
- , Wookjin Shin
- & Jinwoo Cheon
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Article |
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation
Extrusion-based bioprinting has been shown to rapidly and reproducibly generate kidney organoids from a cell-only paste, with the number and maturation of functional units within the kidney tissue capable of being further improved by bioprinting tissue sheets.
- Kynan T. Lawlor
- , Jessica M. Vanslambrouck
- & Melissa H. Little
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Review Article |
Stem-cell-based embryo models for fundamental research and translation
This Review highlights the recent emergence of stem-cell-derived embryo models for the purpose of advancing our understanding of mammalian embryology as well as their potential uses in regenerative and reproductive medicine.
- Jianping Fu
- , Aryeh Warmflash
- & Matthias P. Lutolf
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Review Article |
Rethinking organoid technology through bioengineering
This Review provides an overview of bioengineering technologies that can be harnessed to facilitate the culture, self-organization and functionality of human pluripotent stem cell-derived organoids.
- Elena Garreta
- , Roger D. Kamm
- & Nuria Montserrat
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Article |
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing
Microporous annealed-particle degradable scaffolds have been developed and shown to induce type 2 innate and adaptive immune response that facilitated skin wound healing.
- Donald R. Griffin
- , Maani M. Archang
- & Philip O. Scumpia
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News & Views |
Learning with brain chemistry
Organic neuromorphic devices are now able to take direct input from cellular neurotransmitter release.
- Tobias Cramer
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Review Article |
Materials for flexible bioelectronic systems as chronic neural interfaces
This Review provides an overview of the advances in materials and device design that are enabling the realization of implantable electronic interfaces for long-term, multiplexed recording and stimulation of the brain and nervous system.
- Enming Song
- , Jinghua Li
- & John A. Rogers
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Article |
Enhancement-mode ion-based transistor as a comprehensive interface and real-time processing unit for in vivo electrophysiology
Internal ion-gated organic electrochemical transistors operating in enhancement mode are shown to record electrophysiological signals in vivo, with a speed and sensitivity that enable the detection of action potentials from individual neurons.
- Claudia Cea
- , George D. Spyropoulos
- & Dion Khodagholy
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Article |
Thermoplastic moulding of regenerated silk
Biocompatible and degradable silk materials with programmable mechanical properties can be directly obtained from regenerated amorphous silk using thermal moulding.
- Chengchen Guo
- , Chunmei Li
- & David L. Kaplan
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Article |
Biofuel powered glucose detection in bodily fluids with an n-type conjugated polymer
An n-type semiconducting polymer is used to realize an organic electrochemical transistor working as a glucose sensor and an all-polymer enzymatic biofuel cell able to power the sensor itself.
- David Ohayon
- , Georgios Nikiforidis
- & Sahika Inal
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Letter |
Terahertz circular dichroism spectroscopy of biomaterials enabled by kirigami polarization modulators
Kirigami metamaterials show significant terahertz circular dichroism and are adopted as tunable optical elements in the terahertz region.
- Won Jin Choi
- , Gong Cheng
- & Nicholas A. Kotov
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Article |
Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations
Foreign body response can result in failure of biomaterials in vivo. Solvent-free crystals containing anti-fibrotic drugs now show the potential for long-term inhibition of fibrosis on a number of implantable devices in rodents and non-human primates.
- Shady Farah
- , Joshua C. Doloff
- & Daniel G. Anderson
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Editorial |
Ascent of machine learning in medicine
Machine learning is swiftly infiltrating many areas within the healthcare industry, from diagnosis and prognosis to drug development and epidemiology, with significant potential to transform the medical landscape.
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Article |
Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels
The extracellular matrix surrounding cells plays a significant role in their behaviour. The spreading, mechanosensing and differentiation of mesenchymal stem cells are shown to be dependent on the early deposition and remodelling of local nascent proteins within degradable and viscoelastic hydrogels.
- Claudia Loebel
- , Robert L. Mauck
- & Jason A. Burdick
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Article |
Therapeutic luminal coating of the intestine
The gastrointestinal tract is a therapeutic target for type-2 diabetes. An orally deliverable sucralfate-based material is shown to form a physical coating in the gut, capable of limiting glucose uptake and also administering drugs to the gut lining.
- Yuhan Lee
- , Tara E. Deelman
- & Jeffrey M. Karp
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Article |
Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells
Mechanical cues play critical roles in embryonic development. A micropatterned neuroectoderm developmental model based on human pluripotent stem cells now reveals how morophogenetic signals such as cell shape and contractility regulate neural tissue development.
- Xufeng Xue
- , Yubing Sun
- & Jianping Fu
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News & Views |
Softness makes it better
An effective adjuvant for the induction of humoural and cellular immunity is achieved by a Pickering emulsion formulation that allows pliability and mobility of loaded antigens.
- Herman F. Staats
- & David J. Burkhart
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Article |
Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination
Antigen pliability and lateral mobility in a Pickering emulsion adjuvant may be a safe and effective strategy to enhance adaptive immunity.
- Yufei Xia
- , Jie Wu
- & Guanghui Ma
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Perspective |
Leveraging advances in biology to design biomaterials
Advances in biomaterials have enabled control over desired cell responses. Here, the authors highlight key analytical and bioprocessing techniques, outlining a framework for incorporating these tools into designing functionally optimal biomaterials.
- Max Darnell
- & David J. Mooney
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Article |
Flexible shape-memory scaffold for minimally invasive delivery of functional tissues
Cardiac repair usually requires highly invasive interventional procedures. Here, the authors develop an injectable shape-memory cardiac patch and demonstrated its applicability in a myocardial infarction model.
- Miles Montgomery
- , Samad Ahadian
- & Milica Radisic
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Article |
The microstructure and micromechanics of the tendon–bone insertion
High-resolution imaging, composition analysis and mechanical testing provide a new insight into the structure and function of the Achilles enthesis.
- L. Rossetti
- , L. A. Kuntz
- & A. R. Bausch
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Letter |
Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche
The control of biophysical cues during the culture of human pluripotent stem cells on biomaterial substrates can be used to replicate the in vivo amniogenic environment and direct in vitro generation of early human amniotic tissue.
- Yue Shao
- , Kenichiro Taniguchi
- & Jianping Fu
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Article |
MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells
Mesenchymal stem cells primed on soft silicone substrates suppress fibrogenesis and are desensitized against subsequent mechanical activation in vitro and in vivo.
- Chen Xi Li
- , Nilesh P. Talele
- & Boris Hinz
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Letter |
Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery
Single cells encapsulated in a layer of alginate and injected intravenously delay clearance kinetics and sustain donor-derived soluble factors in vivo.
- Angelo S. Mao
- , Jae-Won Shin
- & David J. Mooney
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Letter |
Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
Heart-on-a-chip devices with integrated strain gauges for direct readout of tissue contractile strength allow for multiplexed drug-dose experiments and studies of functional maturation of cardiac tissue.
- Johan U. Lind
- , Travis A. Busbee
- & Kevin K. Parker
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Letter |
Single-platelet nanomechanics measured by high-throughput cytometry
A high-throughput hydrogel-based platelet-contraction cytometer is able to quantify single-platelet contraction forces and may function as a clinical diagnostic biophysical biomarker.
- David R. Myers
- , Yongzhi Qiu
- & Wilbur A. Lam
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Article |
Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces
A biocompatible and biodegradable mesostructured form of silicon is used to make lipid-bilayer-supported bioelectric interfaces that can optically modulate the electrophysiology of single dorsal root ganglia neurons.
- Yuanwen Jiang
- , João L. Carvalho-de-Souza
- & Bozhi Tian
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Letter |
Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis
Single-cell mechanical homeostasis is found to be driven by the mechanosensitive, collective subcellular dynamics of cytoskeletal tension and focal adhesions.
- Shinuo Weng
- , Yue Shao
- & Jianping Fu
A gentle nerve wrapper
A biopolymer to fight pancreatic cancer