Biomarkers articles within Nature Communications

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  • Article
    | Open Access

    BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes.

    • Helena Escuin-Ordinas
    • , Shuoran Li
    •  & Antoni Ribas

  • Article
    | Open Access

    A tumour’s cell of origin may influence tumour progression and response to therapy. Here, the authors demonstrate that the cell of origin determines the aggressiveness of AML in a mouse model and identify unique biomarkers of the specific leukaemia cell of origin by profiling open chromatin regions of AML samples.

    • Joshy George
    • , Asli Uyar
    •  & Jennifer J. Trowbridge

  • Article
    | Open Access

    The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacological mTOR inhibition.

    • Yoshinori Tsukumo
    • , Tommy Alain
    •  & Nahum Sonenberg

  • Article
    | Open Access

    Exosomes are RNA-containing lipid vesicles with roles in inter-tissue crosstalk. Here the authors show that exosome release from brown adipocytes is increased upon thermogenic activation, both in vitro and in vivo, and demonstrate that serum levels of exosomal miR-92 reflect brown fat activity in humans.

    • Yong Chen
    • , Joschka J. Buyel
    •  & Alexander Pfeifer

  • Article
    | Open Access

    Aging is associated with impaired pancreatic islet function, increased risk of type 2 diabetes, and changes in DNA methylation. Here the authors find blood-based biomarkers that reflect age-associated DNA methylation changes in human pancreatic islets associated with insulin secretion and diabetes.

    • Karl Bacos
    • , Linn Gillberg
    •  & Charlotte Ling

  • Article
    | Open Access

    Regenerative tissue engineering with mesenchymal stem cells is hampered by bulk methods of assessing differentiation status and a general assumption that expression of individual markers of stem cell differentiation correlate with functional capacity. Here the authors debunk this assumption by applying single-cell techniques to disassociate aggrecan mRNA abundance and matrix deposition.

    • Allison J. Cote
    • , Claire M. McLeod
    •  & Robert L. Mauck

  • Article
    | Open Access

    Acquired resistance to anti-angiogenic drugs, including bevacizumab, may occur in cancer patients. In this study the authors identify in the tumour microenvironment, fibrocyte-like cells derived from the bone marrow that mediate the resistance to bevacizumab through the production of FGF2.

    • Atsushi Mitsuhashi
    • , Hisatsugu Goto
    •  & Yasuhiko Nishioka

  • Article
    | Open Access

    DNA circulating in the plasma of cancer patients carries features of the primary tumour, however such DNA is found in low levels in brain cancer patients. Here, the authors show that circulating tumour DNA can be detected in the cerebral spinal fluid of cancer patients and that this better recapitulates the primary tumour compared to DNA from the plasma.

    • Leticia De Mattos-Arruda
    • , Regina Mayor
    •  & Joan Seoane

  • Article
    | Open Access

    In some HIV-1-infected individuals, viraemia remains undetectable after antiretroviral treatment, but which of these patients will experience viral rebound is difficult to predict. Here the authors show that T cell exhaustion markers before treatment are predictive of shorter time to viral rebound.

    • Jacob Hurst
    • , Matthias Hoffmann
    •  & John Frater

  • Article
    | Open Access

    Chemokines and their receptors have key roles in tumorigenesis. Here, the authors demonstrate that CXRC4 is overexpressed in hepatocellular carcinoma and is associated with poor prognosis and, mechanistically CXCR4 is increased in expression via EZH2 repression of microRNA-622.

    • Haiou Liu
    • , Yidong Liu
    •  & Jiejie Xu

  • Article
    | Open Access

    IL6-STAT3 signaling is activated in prostate cancer, however inhibiting this pathway has not lead to a survival advantage in patients. Here, Pencik et al.show that loss of the IL6-STAT3 axis in mice and humans leads to metastasis due to loss of ARF, unravelling STAT3 and ARF as potential prognostic markers in prostate cancer.

    • Jan Pencik
    • , Michaela Schlederer
    •  & Lukas Kenner

  • Article
    | Open Access

    Immune thrombocytopenia (ITP) is caused by autoantibody-mediated platelet clearance, but refractoriness to current immunomodulatory therapies is common. Here the authors show that desialylated platelets can be cleared via hepatic Ashwell–Morell receptor, a process that can be attenuated by sialidase inhibitors, suggesting a new therapy for ITP.

    • June Li
    • , Dianne E. van der Wal
    •  & Heyu Ni

  • Article |

    Increased expression of MITF transcription factor is thought to promote melanoma progression and kinase inhibitor resistance. Here Muller et al. show that MITF loss is also common in melanomas and confers kinase inhibitor resistance due to upregulation of AXL and other receptor tyrosine kinases.

    • Judith Müller
    • , Oscar Krijgsman
    •  & Daniel S. Peeper

  • Article
    | Open Access

    Protein biomarkers could play an important role in the diagnosis and management of diseases. Here the authors investigate the impact of genetic, clinical and lifestyle factors on 92 protein biomarkers for cancer and inflammation and suggest that personalized biomarker thresholds should be used in cancer management.

    • Stefan Enroth
    • , Åsa Johansson
    •  & Ulf Gyllensten

  • Article
    | Open Access

    Alarmins are locally released during inflammation and are early amplifiers of inflammation. Here Vogl et al.show that the alarmin S100A8/S100A9 can be used as a sensitive marker to detect subclinical inflammation and follow disease progression in a variety of disease models.

    • Thomas Vogl
    • , Michel Eisenblätter
    •  & Johannes Roth

  • Article
    | Open Access

    Maternal diet affects DNA methylation in the developing offspring, leading to phenotypic changes. Here, Dominguez-Salas et al. exploit seasonal variation in the diet of Gambian women to show that maternal methyl donor nutrient status around the time of conception predicts methylation levels at metastable epialleles in infants.

    • Paula Dominguez-Salas
    • , Sophie E. Moore
    •  & Branwen J. Hennig

  • Article
    | Open Access

    There has been great interest in attempting to identify gene expression signatures that predict cancer survival. In this study a new algorithm is developed to analyse gene expression datasets that accurately classify both ER+ and ER− breast cancers into low- and high-risk groups.

    • Jie Li
    • , Anne E.G. Lenferink
    •  & Edwin Wang

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