Antibody isolation and purification articles within Nature Communications

Featured

• Article
  17 February 2022 | Open Access

  Development and characterization of functional antibodies targeting NMDA receptors

  Selective targeting individual subtypes of N-methyl-D-aspartate receptors (NMDARs) is a desirable therapeutic strategy for neurological disorders. Here, the authors report identification of a functional antibody that specifically targets and allosterically down-regulates ion channel activity of the GluN1—GluN2B NMDAR subtype.

  • Nami Tajima
  • , Noriko Simorowski
  •  & Hiro Furukawa

• Article
  17 April 2019 | Open Access

  Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

  Human antibodies cross-reactive for several viruses within the Ebolavirus genus have been identified. Here the authors present the crystal structure of such a neutralizing monoclonal antibody (mAb) targeting the stalk of Bundibugyo virus glycoprotein and show that mAb binding may interfere with trimeric bundle assembly and/or the viral membrane.

  • Liam B. King
  • , Brandyn R. West
  •  & Erica Ollmann Saphire

• Article
  12 February 2015 | Open Access

  Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

  Bispecific antibodies allow for novel therapeutic approaches but industrial-scale production and immunogenicity represent significant challenges. Here Fischer et al.describe a unique human bispecific antibody format that exploits differing light chains to overcome these obstacles.

  • Nicolas Fischer
  • , Greg Elson
  •  & Marie Kosco-Vilbois