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    There have been increasingly lively discussions about many published scientific results failing validation by independent studies. This so-called reproducibility crisis has led to criticisms of study design in animal research. Inappropriate statistical methods, poor experimental design, and extreme standardization in trial design may contribute to the problem. The purpose of this Collection is to present original methodologies to improve the status quo and to report meta-research about the reproducibility of published animal research.

    Image: Tetra Images/Getty

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    Some of our best and latest publications on the mechanisms underlying addiction disorders and the effects of addictive substances.

    Image: Shana Novak/Getty

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    A selection of excellent research articles providing insights into the human microbiome and its impact on our health – and disease.

    Image: Roger Harris/Science Photo Library

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    This collection of research, review and comment from Nature Research celebrates the 2020 Nobel Prize in Physiology or Medicine awarded to Harvey J. Alter, Michael Houghton and Charles M. Rice "for the discovery of hepatitis C virus".

    Image: Springer Nature/The Nobel Foundation/Imagesource

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    A collection of some of our latest research into VR tools and the insights they have provided.

    Image: Mina De La O/Getty

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    A collection featuring some of our latest research on diseases transmitted by arthropod vectors, including strategies for mitigation and prevention.

    Image: Smith Collection/Gado

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    There is great scope for machine intelligence to bolster human endeavours to improve health and wellbeing. Here is just a small selection of research published in Scientific Reports that has contributed to the rapid progress of this field in the past few years.

    Image: Dan Prince/Getty

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    This Collection will explore the use of machine learning in all aspects of materials chemistry, from discovering and designing new materials to modelling and optimising their performance, defining structure-property relationships and identifying new applications.

    Image: AF-studio/Getty

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    Psychosocial stress is the consequence of an imbalance between the adverse experiences we meet in our everyday lives and our ability to cope with them. In recent years, psychosocial stress, in its acute and chronic forms, has become a topic of focus across multiple research fields and identified as a key detriment to health and well-being globally. This collection brings forth the latest research into the multifaceted consequences of psychosocial stress on the physical, mental, and social well-being of individuals. In it, we draw particular attention to the effects of social isolation and loneliness, a prominent issue faced in this time of mass lockdown and social distancing.

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    This Collection gathers research articles that focus on the emerging field of Twistronics, spanning from the investigation of new materials/methods to novel applications, as well as related insights into van der Waals heterostructures, that further our understanding.

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    Detecting relevant markers at the clinical point-of-care may facilitate disease prevention and rapid treatment. Medical fields in which samples contain a limited amount of tissue or fluid require point-of-care technologies with improved sensitivity and specificity. The purpose of this Collection is to assemble original research on fluidics-based platforms made of paper or other low-cost materials to precisely manipulate small sample volumes, with a focus on their clinical applications.

    Image: WLADIMIR BULGAR/SCIENCE PHOTO LIBRARY/Getty

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    Scientific Reports has been publishing top-quality research on innovations in electrocatalysis for many years. A natural home for such trans-disciplinary work, here we present a small selection of our most popular papers in this fast-moving field.

    Image: J A Steadman/Getty