This page has been archived and is no longer updated

 

Two possible mechanisms by which epigenetic modification can lead to cancer.

  • Author: Sarah Nelson

Rate & Certify

!
Save | Cancel

Flag Inappropriate

Flag Content | Cancel
Two possible mechanisms by which epigenetic modification can lead to cancer.
(A) A previously unmethylated TS gene such as p53 becomes methylated. Transcription factor(s) (TF) can no longer bind the promoter region, the gene is not expressed, and damaged cells are allowed to proliferate and become cancerous. (B) A proto-oncogene is demethylated, allowing TFs to initiate transcription and express the protein product. As in (A), uncontrolled cell growth ensues and leads to cancer.

This image is linked to the following Scitable pages:

Comparative Methylation Hybridization

How do complex adult-onset disorders take place? The methylation of DNA sequences is an important component of epigenetic control that can be inherited or occur over time.

Comments

Close
* Required

Comments

Please Post Your Comment
No comments yet.

Save Note

Public Private Friends & Groups
Save | Cancel | Delete

 |  |   Close |  Edit |  Delete
Topics
Genetics
Cell Biology
Scientific Communication
Career Planning

Connect
Connect Send a message

Scitable by Nature Education Nature Education Home Learn More About Faculty Page Students Page Feedback


Genetics

Visual Browse

Close