How crossing over can generate copy number variation.

Author: Evan Eichler

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How crossing over can generate copy number variation.

A) In a normal meiosis, chromosomes align precisely at the recombination site and crossovers do not change the number of genes in the recombinant chromosomes. B) The presence of duplicated sequences on a chromosome increases the frequency of chromosome misalignment during meiosis I. Misalignment can result in unequal crossover events that increase the copy number of genes on one recombinant chromosome, while decreasing the copy number of the genes on the other recombinant chromosome.